TRIM11

Gene Symbol	TRIM11
Entrez Gene	81559
Alt Symbol	BIA1, RNF92
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 11
Other Description	E3 ubiquitin-protein ligase TRIM11|RING finger protein 92|tripartite motif-containing 11|tripartite motif-containing protein 11
Swissprots	B3KUS3 Q8NCA6 Q96F44 Q9C022 Q5VSU1 B4DX88 A6NKE2 B2RB82
Accessions	EAW69871 Q96F44 AF220125 AAG53498 AF327056 AAM63957 AK074866 BAC11254 AK097825 BAG53535 AK226119 AK301859 BAG63300 AK314539 BAG37129 AL360165 BC011629 AAH11629 BC069227 AAH69227 EU447015 ABZ92544 XM_011544285 XP_011542587 NM_145214 NP_660215
Function	E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	Ubiquitous.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRIM11 peptide - ab22996 from Abcam Category Peptide Species Human

Human TRIM11 protein fragment - ab164338 from Abcam Category Protein Source Wheat germ Species Human

TRIM11 Antibody Blocking Peptide - LS-E2326 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM11 Antibody Blocking Peptide - LS-E25525 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM11 Antibody Blocking Peptide - LS-E27820 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM11 Antibody Blocking Peptide - LS-E15971 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Trim11 Partial Recombinant Protein - H00081559-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRIM11-Antibody-C-term-Blocking-peptide - BP13284b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRIM11 blocking peptide - GTX89844-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

TRIM11 Peptide - AC21-0354-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRIM11 Peptide - AC21-2631-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRIM11 / RNF92 - H00081559-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TRIM11 / RNF92 - H00081559-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TRIM11 Peptide - 46-517P from ProSci Category Peptide Species Human

TRIM11 Peptide - 42-938P from ProSci Category Peptide Species Human

TRIM11 fusion protein - Ag1308 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human TRIM11, GST-tagged - TRIM11-3405H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase TRIM11(TRIM11) - CSB-YP856931HU CSB-BP856931HU CSB-MP856931HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human E3 ubiquitin-protein ligase TRIM11 - CSB-EP856931HU from Cusabio Category Protein Source E.coli Species Human

TRIM11 / RNF92 - TP309630 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

TRIM11, Peptide - MBS427399 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Pig, Bovine

TRIM11, Peptide - MBS428501 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Human TRIM11 protein - orb244928 from Biorbyt Category Protein Prices $366.00, $595.00, $986.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Trim11 Recombinant Protein Antigen - NBP1-88609PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TRIM11 Peptide, Human - M34GP16565H from Creative Peptides Category Peptide Source Synthetic. Species Human

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