HCST

Gene Symbol HCST
Entrez Gene 10870
Alt Symbol DAP10, KAP10, PIK3AP
Species Human
Gene Type protein-coding
Description hematopoietic cell signal transducer
Other Description DNAX-activation protein 10|kinase assoc pro of ~10kDa|kinase assoc protein|membrane protein DAP10|phosphoinositide-3-kinase adaptor protein|transmembrane adapter protein KAP10
Swissprots Q9UBK5 Q9Y3Y0 Q9UBS1
Accessions AAD46987 Q9UBK5 AF072844 AAD46986 AF122904 AAD47911 AF172929 AAD50293 AF285447 AAG29425 AL050163 CAB43303 AY359058 AAQ89417 BC035931 AAH35931 BC046348 AAH46348 BC065224 AAH65224 NM_001007469 NP_001007470 NM_014266 NP_055081
Function Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST rece
Subcellular Location Membrane {ECO:0000269|PubMed:10426994}; Single-pass type I membrane protein {ECO:0000269|PubMed:10426994}.
Tissue Specificity Predominantly expressed in hemopoietic cells such as NK cells, subset of T-cells and monocytes. Detected in leukocytes, spleen, and thymus. {ECO:0000269|PubMed:10528161}.
Top Pathways Natural killer cell mediated cytotoxicity

Hematopoietic cell signal transducer (HCST), Human, ELISA Kit - E01H1366 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Hematopoietic cell signal transducer, ELISA Kit - MBS280795 from MyBioSource

Category ELISA Kit
Prices $465.00, $790.00, $3,500.00, $6,655.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7222021 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7247891 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7245341 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7251997 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7243039 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7200086 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7231917 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7247549 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7209409 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7252686 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7200738 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Hematopoietic cell signal transducer (HCST), ELISA Kit - MBS7232487 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human HCST ELISA Kit - E018135 from Biobool

Category ELISA Kit

anti-DAP10 / HCST antibody - ARG64104 from Arigo Biolaboratories

Category ELISA Kit
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