HCST

Gene Symbol	HCST
Entrez Gene	10870
Alt Symbol	DAP10, KAP10, PIK3AP
Species	Human
Gene Type	protein-coding
Description	hematopoietic cell signal transducer
Other Description	DNAX-activation protein 10|kinase assoc pro of ~10kDa|kinase assoc protein|membrane protein DAP10|phosphoinositide-3-kinase adaptor protein|transmembrane adapter protein KAP10
Swissprots	Q9UBK5 Q9Y3Y0 Q9UBS1
Accessions	AAD46987 Q9UBK5 AF072844 AAD46986 AF122904 AAD47911 AF172929 AAD50293 AF285447 AAG29425 AL050163 CAB43303 AY359058 AAQ89417 BC035931 AAH35931 BC046348 AAH46348 BC065224 AAH65224 NM_001007469 NP_001007470 NM_014266 NP_055081
Function	Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST rece
Subcellular Location	Membrane {ECO:0000269|PubMed:10426994}; Single-pass type I membrane protein {ECO:0000269|PubMed:10426994}.
Tissue Specificity	Predominantly expressed in hemopoietic cells such as NK cells, subset of T-cells and monocytes. Detected in leukocytes, spleen, and thymus. {ECO:0000269|PubMed:10528161}.
Top Pathways	Natural killer cell mediated cytotoxicity

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DAP10 Antibody Blocking Peptide - LS-E26201 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DAP10/HCST blocking peptide - GTX89210-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Human DAP10 protein - orb139006 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Human Cells Species Human

HCST Peptide - AC21-1032-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DAP10 Peptide - 45-460P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

HCST fusion protein - ag2537 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human HCST, Fc tagged - HCST-130H from Creative Biomart Category Protein Source Human Cell Species Human

Human HCST / DAP10 Protein (Fc Tag) - 14063-H05H-100 from Sino Biological Category Protein Source Human Cells Species Human

Recombinant Human Hematopoietic cell signal transducer(HCST) - CSB-YP010233HU CSB-EP010233HU CSB-BP010233HU CSB-MP010233HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DAP10 / HCST (transcript variant 2) - TP319253 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DAP10/HCST, Peptide - MBS426124 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat

HCST Peptide, Human - M34GP06883H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human HCST / DAP10 Protein (Fc Tag) - 14063-H05H from ABclonal Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source Human Cells Species Human

HCST, 20-48aa, Human, hIgG-His-tag, Baculovirus - ATGP3745 from ATGen Category Protein Prices $80.00, $240.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

HCST Immunizing peptide - orb16896 from Biorbyt Category Peptide

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