| Gene Symbol | HCST |
|---|---|
| Entrez Gene | 10870 |
| Alt Symbol | DAP10, KAP10, PIK3AP |
| Species | Human |
| Gene Type | protein-coding |
| Description | hematopoietic cell signal transducer |
| Other Description | DNAX-activation protein 10|kinase assoc pro of ~10kDa|kinase assoc protein|membrane protein DAP10|phosphoinositide-3-kinase adaptor protein|transmembrane adapter protein KAP10 |
| Swissprots | Q9UBK5 Q9Y3Y0 Q9UBS1 |
| Accessions | AAD46987 Q9UBK5 AF072844 AAD46986 AF122904 AAD47911 AF172929 AAD50293 AF285447 AAG29425 AL050163 CAB43303 AY359058 AAQ89417 BC035931 AAH35931 BC046348 AAH46348 BC065224 AAH65224 NM_001007469 NP_001007470 NM_014266 NP_055081 |
| Function | Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST rece |
| Subcellular Location | Membrane {ECO:0000269|PubMed:10426994}; Single-pass type I membrane protein {ECO:0000269|PubMed:10426994}. |
| Tissue Specificity | Predominantly expressed in hemopoietic cells such as NK cells, subset of T-cells and monocytes. Detected in leukocytes, spleen, and thymus. {ECO:0000269|PubMed:10528161}. |
| Top Pathways | Natural killer cell mediated cytotoxicity |