RPS6KA4

Gene Symbol	RPS6KA4
Entrez Gene	8986
Alt Symbol	MSK2, RSK-B
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 90kDa, polypeptide 4
Other Description	90 kDa ribosomal protein S6 kinase 4|RSKB|S6K-alpha-4|mitogen- and stress-activated protein kinase 2|nuclear mitogen- and stress-activated protein kinase 2|ribosomal protein S6 kinase alpha 4|ribosomal protein S6 kinase alpha-4|ribosomal protein kinase B
Swissprots	O75585 Q53ES8 O75676 A8K7Z8
Accessions	CBX51346 EAW74260 EAW74261 EAW74262 EAW74263 O75676 AF074715 AAC67395 AJ010119 CAA09009 AK223561 BAD97281 AK292163 BAF84852 AK298507 BAG60713 AK313567 BC020451 BC028079 AAH28079 BC047896 AAH47896 BI523588 XM_005274380 XP_005274437 XM_005274381 XP_005274438 NM_001006944 NP_001006945 NM_001300802 NP_001287731 NM_003942 NP_003933
Function	Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide- stimulated primary macrophages, acts downstr
Subcellular Location	Nucleus {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:9792677}.
Top Pathways	MAPK signaling pathway, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human RPS6KA4 / MSK2 / RSK-B ELISA Kit (Cell-Based ELISA) - LS-F2171 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Human Phospho-MSK2 (S360) ELISA - PEL-MSK2-S360 from RayBiotech Category ELISA Kit Prices $481.00, $866.00, $1,924.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

MSK2 Colorimetric Cell-Based ELISA Kit - CB5472 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

ribosomal protein S6 kinase, 90kDa, polypeptide 4, ELISA Kit - MBS9318965 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MSK2 ELISA Kit - DEIA-XYA1235 from Creative Diagnostics Category ELISA Kit

Human MSK2 (Phospho-S360) ELISA Kit - orb247224 from Biorbyt Category ELISA Kit Prices $918.00, $1,573.00, $3,366.00 Sizes 96 assays, 192 assays, 480 assays

Human MSK2 (Phospho-S360) ELISA Kit - orb247225 from Biorbyt Category ELISA Kit Prices $995.00, $1,709.00, $3,672.00 Sizes 96 assays, 192 assays, 480 assays

Human Phospho-MSK2 (S360) ELISA - PEL-MSK2-S360-1 from RayBiotech Category ELISA Kit Prices $491.00, $883.80, $1,964.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Phospho-MSK2 (S360) & Total MSK2 ELISA - PEL-MSK2-S360-T-1 from RayBiotech Category ELISA Kit Prices $536.00, $964.80, $2,144.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human RPS6KA4 ELISA Kit - E033713 from Biobool Category ELISA Kit

MSK2 Colorimetric Cell-Based ELISA Kit - EKA50406 from Biomatik Category ELISA Kit Prices $399.00 Sizes 96 tests Sensitivity At least 5000 cells/well Range Qualitative

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