RPS6KA4

Gene Symbol RPS6KA4
Entrez Gene 8986
Alt Symbol MSK2, RSK-B
Species Human
Gene Type protein-coding
Description ribosomal protein S6 kinase, 90kDa, polypeptide 4
Other Description 90 kDa ribosomal protein S6 kinase 4|RSKB|S6K-alpha-4|mitogen- and stress-activated protein kinase 2|nuclear mitogen- and stress-activated protein kinase 2|ribosomal protein S6 kinase alpha 4|ribosomal protein S6 kinase alpha-4|ribosomal protein kinase B
Swissprots O75585 Q53ES8 O75676 A8K7Z8
Accessions CBX51346 EAW74260 EAW74261 EAW74262 EAW74263 O75676 AF074715 AAC67395 AJ010119 CAA09009 AK223561 BAD97281 AK292163 BAF84852 AK298507 BAG60713 AK313567 BC020451 BC028079 AAH28079 BC047896 AAH47896 BI523588 XM_005274380 XP_005274437 XM_005274381 XP_005274438 NM_001006944 NP_001006945 NM_001300802 NP_001287731 NM_003942 NP_003933
Function Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide- stimulated primary macrophages, acts downstr
Subcellular Location Nucleus {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:9792677}.
Top Pathways MAPK signaling pathway, TNF signaling pathway

Human-RPS6KA4-cDNA-Clone - DC07727 from Abgent, a WuXi AppTec company

Prices $707.40
Sizes 10 µg
Species Human
Accession BC047896

RPS6KA4 - MBS1266556 from MyBioSource

Species Human
Accession BC047896

Human RPS6KA4 cDNA clone(NM_001006944.1) - CDFH016680 from Creative Biomart

Species Human
Accession NM_001006944.1

Human RPS6KA4 cDNA clone(NM_003942.2) - CDFH016681 from Creative Biomart

Species Human
Accession NM_003942.2

Human RPS6KA4 cDNA clone(NM_003942.2) - CDFH016682 from Creative Biomart

Species Human
Accession NM_003942.2

Human RPS6KA4 ORF Clone(NM_001006944.1) - CDCL174229 from Creative Biomart

Species Human
Accession NM_001006944.1

Human RPS6KA4 ORF Clone(NM_003942.2) - CDCR286815 from Creative Biomart

Species Human
Accession NM_003942.2

Human RPS6KA4 ORF Clone(NM_003942.2) - CDCR286816 from Creative Biomart

Species Human
Accession NM_003942.2

Human RPS6KA4 ORF Clone(NM_001006944.1) - CDCR339771 from Creative Biomart

Species Human
Accession NM_001006944.1

Human RPS6KA4 ORF Clone(NM_001006944.1) - CDCR340090 from Creative Biomart

Species Human
Accession NM_001006944.1

Human RPS6KA4 ORF Clone(NM_003942.2) - CDCR286815 from Creative biogene

Species Human

human RPS6KA4 ORF clone (NM_001006944.1) - CDCH075708 from Creative biogene

Species Human

Human RPS6KA4 ORF Clone (BC047896) - CDCS406295 from Creative biogene

Species Human
Accession O75676

Human RPS6KA4 cDNA Clone(NM_001006944.1) - CDFH016680 from Creative biogene

Species Human

Human RPS6KA4 cDNA Clone(NM_003942.2) - CDFH016681 from Creative biogene

Species Human

Human RPS6KA4 cDNA Clone(NM_003942.2) - CDFH016682 from Creative biogene

Species Human
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