RPS6KA4
| Gene Symbol | RPS6KA4 |
|---|---|
| Entrez Gene | 8986 |
| Alt Symbol | MSK2, RSK-B |
| Species | Human |
| Gene Type | protein-coding |
| Description | ribosomal protein S6 kinase, 90kDa, polypeptide 4 |
| Other Description | 90 kDa ribosomal protein S6 kinase 4|RSKB|S6K-alpha-4|mitogen- and stress-activated protein kinase 2|nuclear mitogen- and stress-activated protein kinase 2|ribosomal protein S6 kinase alpha 4|ribosomal protein S6 kinase alpha-4|ribosomal protein kinase B |
| Swissprots | O75585 Q53ES8 O75676 A8K7Z8 |
| Accessions | CBX51346 EAW74260 EAW74261 EAW74262 EAW74263 O75676 AF074715 AAC67395 AJ010119 CAA09009 AK223561 BAD97281 AK292163 BAF84852 AK298507 BAG60713 AK313567 BC020451 BC028079 AAH28079 BC047896 AAH47896 BI523588 XM_005274380 XP_005274437 XM_005274381 XP_005274438 NM_001006944 NP_001006945 NM_001300802 NP_001287731 NM_003942 NP_003933 |
| Function | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide- stimulated primary macrophages, acts downstr |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:9792677}. |
| Top Pathways | MAPK signaling pathway, TNF signaling pathway |
MSK2 CRISPR/Cas9 KO Plasmid (h) - sc-404150 from Santa Cruz Biotechnology
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MSK2 HDR Plasmid (h) - sc-404150-HDR from Santa Cruz Biotechnology
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MSK2 Double Nickase Plasmid (h) - sc-404150-NIC from Santa Cruz Biotechnology
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MSK2 Double Nickase Plasmid (h2) - sc-404150-NIC-2 from Santa Cruz Biotechnology
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MSK2 CRISPR Activation Plasmid (h) - sc-404150-ACT from Santa Cruz Biotechnology
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MSK2 CRISPR Activation Plasmid (h2) - sc-404150-ACT-2 from Santa Cruz Biotechnology
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MSK2 Lentiviral Activation Particles (h) - sc-404150-LAC from Santa Cruz Biotechnology
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MSK2 Lentiviral Activation Particles (h2) - sc-404150-LAC-2 from Santa Cruz Biotechnology
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MSK2 siRNA (h) - sc-75836 from Santa Cruz Biotechnology
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MSK2 shRNA Plasmid (h) - sc-75836-SH from Santa Cruz Biotechnology
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MSK2 shRNA (h) Lentiviral Particles - sc-75836-V from Santa Cruz Biotechnology
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MSK2 RNAi - H00008986-R03 from Novus Biologicals
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MISSION® esiRNA - EHU079611 from Sigma-Aldrich
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MISSION® siRNA - SIHK2015 from Sigma-Aldrich
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MISSION® siRNA - SIHK2014 from Sigma-Aldrich
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MISSION® siRNA - SIHK2013 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18655 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18655 from Sigma-Aldrich
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RPS6KA4 siRNA (Human) - CRH5928 from Cohesion Biosciences
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MSK2 RNAi - H00008986-R04 from Novus Biologicals
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RPS6KA4 - MBS827194 from MyBioSource
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shRNA set against Human RPS6KA4 (NM_003942.2) - SHH399576 from Creative biogene
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shRNA set against Human RPS6KA4(NM_001006944.1) - SHR197772 from Creative biogene
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shRNA set against Human RPS6KA4(NM_003942.2) - SHR197968 from Creative biogene
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shRNA set against Human RPS6KA4(NM_001006944.1) - SHR197992 from Creative biogene
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