RPS6KA4

Gene Symbol	RPS6KA4
Entrez Gene	8986
Alt Symbol	MSK2, RSK-B
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 90kDa, polypeptide 4
Other Description	90 kDa ribosomal protein S6 kinase 4|RSKB|S6K-alpha-4|mitogen- and stress-activated protein kinase 2|nuclear mitogen- and stress-activated protein kinase 2|ribosomal protein S6 kinase alpha 4|ribosomal protein S6 kinase alpha-4|ribosomal protein kinase B
Swissprots	O75585 Q53ES8 O75676 A8K7Z8
Accessions	CBX51346 EAW74260 EAW74261 EAW74262 EAW74263 O75676 AF074715 AAC67395 AJ010119 CAA09009 AK223561 BAD97281 AK292163 BAF84852 AK298507 BAG60713 AK313567 BC020451 BC028079 AAH28079 BC047896 AAH47896 BI523588 XM_005274380 XP_005274437 XM_005274381 XP_005274438 NM_001006944 NP_001006945 NM_001300802 NP_001287731 NM_003942 NP_003933
Function	Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide- stimulated primary macrophages, acts downstr
Subcellular Location	Nucleus {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:9792677}.
Top Pathways	MAPK signaling pathway, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active mouse MSK2 / RSK-B full length protein - ab125610 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Mouse

Human MSK2 / RSK-B peptide - ab42280 from Abcam Category Peptide

Human MSK2 / RSK-B peptide - ab42281 from Abcam Category Peptide

RPS6KA4 / MSK2 / RSK-B Antibody Blocking Peptide - LS-E22937 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RPS6KA4 / MSK2 / RSK-B Antibody Blocking Peptide - LS-E8603 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MSK2 Protein - H00008986-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

RSKB-MSK2-Antibody-C-term-R321-Blocking-peptide - BP7011a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MSK2 - H00008986-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

MSK2 - P5604 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

RPS6KA4 fusion protein - Ag7414 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RPS6KA4 fusion protein - Ag6098 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human RPS6KA4, His-tagged - RPS6KA4-29913TH from Creative Biomart Category Protein Source E. coli

Recombinant Human RPS6KA4, His-tagged - RPS6KA4-2434H from Creative Biomart Category Protein Source E.coli Species Human

MSK2 Protein, active, 250 µg - 14-616M from EMD Millipore Category Protein Prices $3,059.00 Sizes 250 µg also available in 10 μg size . (cat#14-616) and in bulk (cat#14-616-K) Source expressed by baculovirus in Sf21 insect cells

MSK2 Protein, active, 10 µg - 14-616 from EMD Millipore Category Protein Prices $349.00 Sizes 10 µg Source expressed by baculovirus in Sf21 insect cells

Recombinant Human Ribosomal protein S6 kinase alpha-4(RPS6KA4) - CSB-YP020467HU CSB-EP020467HU CSB-BP020467HU CSB-MP020467HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MSK2 (transcript variant 1) - TP312570 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MSK2 Recombinant Protein Antigen - NBP1-87844PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RSKB-MSK2-Antibody-N-term-Blocking-peptide - BP7011c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RSKB-MSK2-Antibody-C-term-Blocking-peptide - BP7011b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RPS6KA4-Blocking-Peptide-Center - BP20357c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RPS6KA4-Blocking-Peptide-C-term - BP21318b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RPS6KA4-Blocking-Peptide-C-term - BP21317b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RPS6KA4 Peptide, Human - M34GP13598H from Creative Peptides Category Peptide Source Synthetic. Species Human

Ribosomal protein S6 kinase alpha-4 (RPS6KA4), Recombinant Protein - MBS1131673 from MyBioSource Category Protein Prices $1,590.00, $1,590.00, $1,815.00, $1,815.00, $2,745.00, $2,745.00, $3,185.00, $3,185.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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