RPS6KA4

Gene Symbol RPS6KA4
Entrez Gene 8986
Alt Symbol MSK2, RSK-B
Species Human
Gene Type protein-coding
Description ribosomal protein S6 kinase, 90kDa, polypeptide 4
Other Description 90 kDa ribosomal protein S6 kinase 4|RSKB|S6K-alpha-4|mitogen- and stress-activated protein kinase 2|nuclear mitogen- and stress-activated protein kinase 2|ribosomal protein S6 kinase alpha 4|ribosomal protein S6 kinase alpha-4|ribosomal protein kinase B
Swissprots O75585 Q53ES8 O75676 A8K7Z8
Accessions CBX51346 EAW74260 EAW74261 EAW74262 EAW74263 O75676 AF074715 AAC67395 AJ010119 CAA09009 AK223561 BAD97281 AK292163 BAF84852 AK298507 BAG60713 AK313567 BC020451 BC028079 AAH28079 BC047896 AAH47896 BI523588 XM_005274380 XP_005274437 XM_005274381 XP_005274438 NM_001006944 NP_001006945 NM_001300802 NP_001287731 NM_003942 NP_003933
Function Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide- stimulated primary macrophages, acts downstr
Subcellular Location Nucleus {ECO:0000269|PubMed:11035004, ECO:0000269|PubMed:9792677}.
Top Pathways MAPK signaling pathway, TNF signaling pathway

MSK2 (D41A4) XP ® Rabbit mAb - 3679 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D41A4
Western blot analysis of extracts from HeLa and A-431 cells, untreated or treated with Calyculin A #9902 (100 nM, 30 minutes), using MSK2 (D41A4) XP ® Rabbit mAb.

MSK2 (F-2) - sc-377151 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MSK2 (F-2): sc-377151. Western blot analysis of MSK2 expression in non-transfected: sc-117752 (A) and mouse MSK2 transfected: sc-121804 (B) 293T whole cell lysates.

MSK2 (H-50) - sc-98524 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MSK2 (H-50): sc-98524. Western blot analysis of MSK2 expression in A-431 whole cell lysate.

MSK2 (E-16) - sc-82229 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MSK2 (Y-15) - sc-82231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MSK2 (Y-15): sc-82231. Western blot analysis of MSK2 expression in non-transfected: sc-117752 (A) and mouse MSK2 transfected: sc-121804 (B) 293T whole cell lysates.

MSK2 (2934C1a) - sc-130653 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
MSK2 (2934C1a): sc-130653. Western blot analysis of MSK2 expression in non-transfected: sc-117752 (A) and mouse MSK2 transfected: sc-121804 (B) 293T whole cell lysates.

Anti-MSK2 / RSK-B (phospho T568) antibody - ab79502 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MSK2 / RSK-B (phospho T568) antibody (ab79502) at 1/1000 dilutionLane 1 : extracts from 293 cells (treated with H2O2 at 100uM for 15mins)Lane 2 : extracts from 293 cells (treated with H2O2 at 100uM for 15mins) with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-MSK2 / RSK-B antibody - ab42101 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MSK2 / RSK-B antibody (ab42101) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : HeLa (Human epithelial carcinoma cell line) Nuclear Lysate Lane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-MSK2 / RSK-B antibody - ab99411 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling MSK2 / RSK-B with ab99411 at 1/200 (1µg/mg). Detection: DAB.

Anti-MSK2 / RSK-B antibody - ab51131 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MSK2 / RSK-B antibody (ab51131) at 1/2000 dilutionLane 1 : A431 cell lysateLane 2 : 293T cell lysate

Anti-MSK2 / RSK-B antibody - ab196736 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MSK2 / RSK-B antibody (ab196736) at 1/500 dilutionLane 1 : Extracts from RAW264.7 cells treated with UV (5mins)Lane 2 : Extracts from RAW264.7 cells treated with UV (5mins) with synthesized peptide

Anti-MSK2 / RSK-B antibody [2934C1a] - ab71964 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2934C1a
Anti-MSK2 / RSK-B antibody [2934C1a] (ab71964) at 1/100 dilution + immunising recombinant protein at 0.025 µgSecondarySheep Anti Mouse IgG at 1/3000 dilution

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (phospho-Ser360) - LS-C3309 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (C-Terminus) - LS-C16612 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (clone 2934C1a) - LS-C184679 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2934C1a

Anti-RPS6KA4 / MSK2 / RSK-B Antibody - LS-C62216 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (aa315-344, AP) - LS-C268633 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (aa315-344, APC) - LS-C285152 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (aa315-344, Biotin) - LS-C285153 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (aa315-344, FITC) - LS-C285154 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (aa315-344, Azide-free, HRP) - LS-C285155 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (C-Terminus) - LS-C145909 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RPS6KA4 / MSK2 antibody LS-C145909 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (aa315-344, PE) - LS-C285157 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (aa481-508) - LS-C203841 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RPS6KA4 Antibody western blot of U251 cell line lysates (35 ug/lane). The RPS6KA4 antibody detected the RPS6KA4 protein (arrow).

Anti-RPS6KA4 / MSK2 / RSK-B Antibody (aa315-344) - LS-C330083 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more