| Gene Symbol |
ASAP2
|
| Entrez Gene |
8853
|
| Alt Symbol |
AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
|
| Other Description |
PYK2 C terminus-associated protein|arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2|centaurin, beta 3|development and differentiation enhancing factor 2|development and differentiation-enhancing factor 2|paxillin-associated protein with ARF GAP activity 3|pyk2 C-terminus-associated protein
|
| Swissprots |
D6W4Y8 O43150
|
| Accessions |
AAY14856 AAY14904 AAY24112 EAX01002 EAX01003 EAX01004 EAX01005 EAX01006 O43150 AA918883 AB007860 BAA23696 AK091121 BAC03588 AK123185 AK124900 BC063308 AAH63308 XM_006711898 XP_006711961 XM_006711901 XP_006711964 XM_006711902 XP_006711965 XM_011510403 XP_011508705 XM_011510404 XP_011508706 XM_011510405 XP_011508707 XM_011510406 XP_011508708 XM_011510407 XP_011508709 XM_011510408 XP_011508710 XM_011510409 XP_011508711 NM_001135191 NP_001128663 NM_003887 NP_003878
|
| Function |
Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:10749932, ECO:0000269|PubMed:11304556}.
|
| Subcellular Location |
Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin and ARF6 in phagocytic cups.
|
| Tissue Specificity |
Detected in heart, brain, placenta, kidney, monocytes and pancreas. {ECO:0000269|PubMed:10022920}.
|
| Top Pathways |
Fc gamma R-mediated phagocytosis, Endocytosis
|