Gene Symbol | TRAF1 |
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Entrez Gene | 7185 |
Alt Symbol | EBI6, MGC:10353 |
Species | Human |
Gene Type | protein-coding |
Description | TNF receptor-associated factor 1 |
Other Description | Epstein-Bar virus-induced protein 6 |
Swissprots | Q8NF13 Q13077 B4DJ77 Q658U1 |
Accessions | CBX47545 EAW87479 Q13077 AK090468 BAC03449 AK295959 BAG58739 AK315476 BAG37860 AL832989 CAH56343 AW014547 BC024145 AAH24145 BT019408 AAV38215 HQ447750 ADQ32235 U19261 AAA62309 NM_001190945 NP_001177874 NM_001190947 NP_001177876 NM_005658 NP_005649 |
Function | Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093}. |
Top Pathways | Small cell lung cancer, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection, TNF signaling pathway |
TRAF1 (1F3) Rat mAb - 4710 from Cell Signaling Technology
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TRAF1 (45D3) Rabbit mAb - 4715 from Cell Signaling Technology
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TRAF1 Antibody - 4714 from Cell Signaling Technology
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TRAF1 (G-20) - sc-983 from Santa Cruz Biotechnology
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TRAF1 (H-125) - sc-1830 from Santa Cruz Biotechnology
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TRAF1 (H-132) - sc-1831 from Santa Cruz Biotechnology
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TRAF1 (H-186) - sc-7186 from Santa Cruz Biotechnology
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TRAF1 (H-3) - sc-6253 from Santa Cruz Biotechnology
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Anti-TRAF1 antibody - ab129279 from Abcam
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Anti-TRAF1 antibody - ab197684 from Abcam
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Anti-TRAF1 antibody - ab167652 from Abcam
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Anti-TRAF1 antibody - ab116313 from Abcam
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Anti-TRAF1 antibody - ab48002 from Abcam
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Anti-TRAF1 antibody - ab155268 from Abcam
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Anti-TRAF1 antibody - ab37410 from Abcam
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Anti-TRAF1 Antibody (aa270-282) IHC-plus⢠- LS-B6466 from LifeSpan Bioscience
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Anti-TRAF1 Antibody (aa55-83, FITC) - LS-C224420 from LifeSpan Bioscience
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Anti-TRAF1 Antibody (aa55-83, Biotin) - LS-C224419 from LifeSpan Bioscience
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Anti-TRAF1 Antibody (aa55-83, APC) - LS-C224418 from LifeSpan Bioscience
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Anti-TRAF1 Antibody (aa55-83, Azide-free, HRP) - LS-C224421 from LifeSpan Bioscience
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Anti-TRAF1 Antibody (aa55-83, AP) - LS-C224417 from LifeSpan Bioscience
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Anti-TRAF1 Antibody (aa55-83, PE) - LS-C224422 from LifeSpan Bioscience
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Anti-TRAF1 Antibody (aa54-83) - LS-C325904 from LifeSpan Bioscience
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Anti-TRAF1 Antibody (clone 3D4) - LS-C343625 from LifeSpan Bioscience
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Anti-TRAF1 Antibody (C-Terminus) - LS-C112308 from LifeSpan Bioscience
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