Gene Symbol | TRAF1 |
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Entrez Gene | 7185 |
Alt Symbol | EBI6, MGC:10353 |
Species | Human |
Gene Type | protein-coding |
Description | TNF receptor-associated factor 1 |
Other Description | Epstein-Bar virus-induced protein 6 |
Swissprots | Q8NF13 Q13077 B4DJ77 Q658U1 |
Accessions | CBX47545 EAW87479 Q13077 AK090468 BAC03449 AK295959 BAG58739 AK315476 BAG37860 AL832989 CAH56343 AW014547 BC024145 AAH24145 BT019408 AAV38215 HQ447750 ADQ32235 U19261 AAA62309 NM_001190945 NP_001177874 NM_001190947 NP_001177876 NM_005658 NP_005649 |
Function | Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093}. |
Top Pathways | Small cell lung cancer, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection, TNF signaling pathway |
Human TRAF1 full length protein - ab132353 from Abcam
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Human TRAF1 peptide - ab48049 from Abcam
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Human TRAF1 protein fragment - ab95858 from Abcam
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Human TRAF1 protein fragment - ab117184 from Abcam
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TRAF1 Antibody Blocking Peptide - LS-E2831 from LifeSpan Bioscience
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TRAF1 Antibody Blocking Peptide - LS-E10530 from LifeSpan Bioscience
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TRAF1 Antibody Blocking Peptide - LS-E26059 from LifeSpan Bioscience
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TRAF-1 Recombinant Protein - H00007185-P01 from Novus Biologicals
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Recombinant Human TRAF-1 Protein - NBP1-44457 from Novus Biologicals
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TRAF1-Antibody-N-term-Blocking-peptide - BP13946a from Abgent, a WuXi AppTec company
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TRAF1 blocking peptide - GTX89381-PEP from GeneTex
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TRAF1 Protein (OPPA02382) - OPPA02382 from Aviva Systems Biology
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Human TRAF1 protein - orb81427 from Biorbyt
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TRAF1 Blocking Peptide - 33R-1850 from Fitzgerald
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TRAF1 protein (His tag) - 80R-1335 from Fitzgerald
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TRAF1 Peptide - AC21-0887-P from Abcore
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TRAF1 / EBI6 (266-416, His-tag) - AR09508PU-L from Acris Antibodies
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TRAF1 / EBI6 (266-416, His-tag) - AR09508PU-N from Acris Antibodies
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TRAF1 / EBI6 - H00007185-P01-10 from Acris Antibodies
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TRAF1 / EBI6 - H00007185-P01-25 from Acris Antibodies
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TNF receptor-Associated Factor 1, Human Recombinant - 228-13275-1 from RayBiotech
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Recombinant Human TNF receptor-Associated Factor 1 - 228-13275-2 from RayBiotech
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Recombinant Human TNF receptor-Associated Factor 1 - 228-13275-3 from RayBiotech
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TRAF1, 266-416aa, Human, His tag, E.coli - 01-1840-1 from ARP American Research Products
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TRAF1 Peptide - 46-509P from ProSci
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