Gene Symbol | TRAF1 |
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Entrez Gene | 7185 |
Alt Symbol | EBI6, MGC:10353 |
Species | Human |
Gene Type | protein-coding |
Description | TNF receptor-associated factor 1 |
Other Description | Epstein-Bar virus-induced protein 6 |
Swissprots | Q8NF13 Q13077 B4DJ77 Q658U1 |
Accessions | CBX47545 EAW87479 Q13077 AK090468 BAC03449 AK295959 BAG58739 AK315476 BAG37860 AL832989 CAH56343 AW014547 BC024145 AAH24145 BT019408 AAV38215 HQ447750 ADQ32235 U19261 AAA62309 NM_001190945 NP_001177874 NM_001190947 NP_001177876 NM_005658 NP_005649 |
Function | Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093}. |
Top Pathways | Small cell lung cancer, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection, TNF signaling pathway |
TRAF1 CRISPR/Cas9 KO Plasmid (h) - sc-401824 from Santa Cruz Biotechnology
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TRAF1 HDR Plasmid (h) - sc-401824-HDR from Santa Cruz Biotechnology
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TRAF1 Double Nickase Plasmid (h) - sc-401824-NIC from Santa Cruz Biotechnology
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TRAF1 Double Nickase Plasmid (h2) - sc-401824-NIC-2 from Santa Cruz Biotechnology
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TRAF1 CRISPR Activation Plasmid (h) - sc-401824-ACT from Santa Cruz Biotechnology
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TRAF1 CRISPR Activation Plasmid (h2) - sc-401824-ACT-2 from Santa Cruz Biotechnology
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TRAF1 Lentiviral Activation Particles (h) - sc-401824-LAC from Santa Cruz Biotechnology
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TRAF1 Lentiviral Activation Particles (h2) - sc-401824-LAC-2 from Santa Cruz Biotechnology
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TRAF1 siRNA (h) - sc-29508 from Santa Cruz Biotechnology
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TRAF1 shRNA Plasmid (h) - sc-29508-SH from Santa Cruz Biotechnology
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TRAF1 shRNA (h) Lentiviral Particles - sc-29508-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU040431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21903 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21903 from Sigma-Aldrich
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TRAF1 siRNA (Human) - CRH4934 from Cohesion Biosciences
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TRAF-1 RNAi - H00007185-R01 from Novus Biologicals
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TRAF1 - MBS8201980 from MyBioSource
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shRNA set against Human TRAF1 (NM_005658.4) - SHH433680 from Creative biogene
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Human TRAF1 siRNA - orb265436 from Biorbyt
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TRAF1 shRNA Plasmid (Human) - CHH4934 from Cohesion Biosciences
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TRAF1 miRNA 3'UTR clone - MiUTR4H-TG09301 from Creative biogene
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