| Gene Symbol |
TRAF1
|
| Entrez Gene |
7185
|
| Alt Symbol |
EBI6, MGC:10353
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TNF receptor-associated factor 1
|
| Other Description |
Epstein-Bar virus-induced protein 6
|
| Swissprots |
Q8NF13 Q13077 B4DJ77 Q658U1
|
| Accessions |
CBX47545 EAW87479 Q13077 AK090468 BAC03449 AK295959 BAG58739 AK315476 BAG37860 AL832989 CAH56343 AW014547 BC024145 AAH24145 BT019408 AAV38215 HQ447750 ADQ32235 U19261 AAA62309 NM_001190945 NP_001177874 NM_001190947 NP_001177876 NM_005658 NP_005649
|
| Function |
Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093}.
|
| Top Pathways |
Small cell lung cancer, Herpes simplex infection, Viral carcinogenesis, Epstein-Barr virus infection, TNF signaling pathway
|
![Western Blot: TRAF1 Overexpression Lysate (Adult Normal) [NBL1-17239] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TRAF1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11171_TRAF1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-17239-img0002.jpg)