| Gene Symbol |
TBXA2R
|
| Entrez Gene |
6915
|
| Alt Symbol |
BDPLT13, TXA2-R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thromboxane A2 receptor
|
| Other Description |
prostanoid TP receptor
|
| Swissprots |
P21731 Q9UCY1 Q6DK52 Q9UCY2 O75228
|
| Accessions |
AAC24302 AAC24303 ABB72549 BAA03649 EAW69301 EAW69302 P21731 AY429110 AAR07905 BC028027 AAH28027 BC074749 AAH74749 BC074750 AAH74750 BC121148 AAI21149 BC121149 AAI21150 BM990145 U11271 AAA58957 U27325 AAA68608 XM_011528214 XP_011526516 NM_001060 NP_001051 NM_201636 NP_963998
|
| Function |
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. {ECO:0000269|PubMed:8613548}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
Calcium signaling pathway, Neuroactive ligand-receptor interaction
|
![Western Blot: Thromboxane A2 receptor Overexpression Lysate (Adult Normal) [NBL1-16752] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Thromboxane A2 receptor.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8167_Thromboxane%2520A2%2520receptor%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16752-img0002.jpg)