Gene Symbol | TBXA2R |
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Entrez Gene | 6915 |
Alt Symbol | BDPLT13, TXA2-R |
Species | Human |
Gene Type | protein-coding |
Description | thromboxane A2 receptor |
Other Description | prostanoid TP receptor |
Swissprots | P21731 Q9UCY1 Q6DK52 Q9UCY2 O75228 |
Accessions | AAC24302 AAC24303 ABB72549 BAA03649 EAW69301 EAW69302 P21731 AY429110 AAR07905 BC028027 AAH28027 BC074749 AAH74749 BC074750 AAH74750 BC121148 AAI21149 BC121149 AAI21150 BM990145 U11271 AAA58957 U27325 AAA68608 XM_011528214 XP_011526516 NM_001060 NP_001051 NM_201636 NP_963998 |
Function | Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. {ECO:0000269|PubMed:8613548}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
TXA2R CRISPR/Cas9 KO Plasmid (h) - sc-402468 from Santa Cruz Biotechnology
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TXA2R HDR Plasmid (h) - sc-402468-HDR from Santa Cruz Biotechnology
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TXA2R Double Nickase Plasmid (h) - sc-402468-NIC from Santa Cruz Biotechnology
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TXA2R Double Nickase Plasmid (h2) - sc-402468-NIC-2 from Santa Cruz Biotechnology
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TXA2R CRISPR Activation Plasmid (h) - sc-402468-ACT from Santa Cruz Biotechnology
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TXA2R CRISPR Activation Plasmid (h2) - sc-402468-ACT-2 from Santa Cruz Biotechnology
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TXA2R Lentiviral Activation Particles (h) - sc-402468-LAC from Santa Cruz Biotechnology
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TXA2R Lentiviral Activation Particles (h2) - sc-402468-LAC-2 from Santa Cruz Biotechnology
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TXA2R siRNA (h) - sc-40226 from Santa Cruz Biotechnology
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TXA2R shRNA Plasmid (h) - sc-40226-SH from Santa Cruz Biotechnology
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TXA2R shRNA (h) Lentiviral Particles - sc-40226-V from Santa Cruz Biotechnology
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Thromboxane A2 R/TBXA2R RNAi - H00006915-R04 from Novus Biologicals
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Thromboxane A2 R/TBXA2R RNAi - H00006915-R03 from Novus Biologicals
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MISSION® esiRNA - EHU140211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1892 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1892 from Sigma-Aldrich
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TBXA2R siRNA (Human) - CRH4739 from Cohesion Biosciences
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TBXA2R - MBS8219141 from MyBioSource
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TXA2R CRISPR/Cas9 KO Plasmid (h2) - sc-402468-KO-2 from Santa Cruz Biotechnology
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TXA2R HDR Plasmid (h2) - sc-402468-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TBXA2R (NM_001060.5) - SHH424488 from Creative biogene
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Human TBXA2R siRNA - orb265241 from Biorbyt
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TBXA2R shRNA Plasmid (Human) - CHH4739 from Cohesion Biosciences
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TBXA2R miRNA 3'UTR clone - MiUTR3H-02211 from Creative biogene
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TBXA2R miRNA 3'UTR clone - MiUTR3H-02212 from Creative biogene
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