| Gene Symbol |
NEK7
|
| Entrez Gene |
140609
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NIMA-related kinase 7
|
| Other Description |
NIMA (never in mitosis gene a)-related kinase 7|never in mitosis A-related kinase 7|nimA-related protein kinase 7|serine/threonine-protein kinase Nek7
|
| Swissprots |
Q8TDX7 A6NGT8
|
| Accessions |
EAW91293 EAW91294 EAW91295 EAW91296 Q8TDX7 AB062450 BAB85632 AK313411 BAG36205 AL080111 BC043003 BC152872 AAI52873 BC156616 AAI56617 DB498485 XM_011509208 XP_011507510 XM_011509209 XP_011507511 NM_133494 NP_598001
|
| Function |
Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. {ECO:0000269|PubMed:17101132, ECO:0000269|PubMed:17586473, ECO:0000269|PubMed:19414596}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody.
|
| Tissue Specificity |
Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine. {ECO:0000269|PubMed:11701951}.
|