Gene Symbol | NEK7 |
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Entrez Gene | 140609 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | NIMA-related kinase 7 |
Other Description | NIMA (never in mitosis gene a)-related kinase 7|never in mitosis A-related kinase 7|nimA-related protein kinase 7|serine/threonine-protein kinase Nek7 |
Swissprots | Q8TDX7 A6NGT8 |
Accessions | EAW91293 EAW91294 EAW91295 EAW91296 Q8TDX7 AB062450 BAB85632 AK313411 BAG36205 AL080111 BC043003 BC152872 AAI52873 BC156616 AAI56617 DB498485 XM_011509208 XP_011507510 XM_011509209 XP_011507511 NM_133494 NP_598001 |
Function | Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. {ECO:0000269|PubMed:17101132, ECO:0000269|PubMed:17586473, ECO:0000269|PubMed:19414596}. |
Subcellular Location | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody. |
Tissue Specificity | Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine. {ECO:0000269|PubMed:11701951}. |
Active human NEK7 full length protein - ab196067 from Abcam
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Active human NEK7 full length protein - ab60703 from Abcam
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Human NEK7 full length protein - ab136361 from Abcam
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NEK7 Antibody Blocking Peptide - LS-E27537 from LifeSpan Bioscience
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NEK7 Antibody Blocking Peptide - LS-E27536 from LifeSpan Bioscience
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NEK7 Antibody Blocking Peptide - LS-E17725 from LifeSpan Bioscience
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NEK7 Antibody Blocking Peptide - LS-E17726 from LifeSpan Bioscience
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NEK7 Antibody Blocking Peptide - LS-E9475 from LifeSpan Bioscience
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NEK7 Antibody Blocking Peptide - LS-E29233 from LifeSpan Bioscience
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NEK7 Antibody Blocking Peptide - LS-E29234 from LifeSpan Bioscience
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NEK7 Partial Recombinant Protein - H00140609-Q01 from Novus Biologicals
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NEK7 Recombinant Protein - H00140609-P01 from Novus Biologicals
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Recombinant Human NEK7 Protein - NBP2-23287 from Novus Biologicals
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NEK7 Recombinant Protein - P4201 from Novus Biologicals
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NEK7 Recombinant Protein - P4733 from Novus Biologicals
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NEK7 Protein - NBP1-99496 from Novus Biologicals
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NEK7 Peptide - P3074 from Novus Biologicals
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NEK7-Antibody-N-term-Blocking-Peptide - BP8078a from Abgent, a WuXi AppTec company
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NEK7 (Active) recombinant protein - GTX65461 from GeneTex
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Human NEK7 His GST tag protein - orb83911 from Biorbyt
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Human NEK7 protein - orb168919 from Biorbyt
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NEK7 Blocking Peptide - 33R-4257 from Fitzgerald
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NEK7 protein - 30R-2832 from Fitzgerald
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NEK7 protein (His tag) - 80R-2565 from Fitzgerald
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NEK7 Peptide - AC21-2358-P from Abcore
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