| Gene Symbol |
FCHO2
|
| Entrez Gene |
115548
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FCH domain only 2
|
| Other Description |
F-BAR domain only protein 2|FCH domain only protein 2
|
| Swissprots |
E9PG79 B2RNQ9 Q96CF5 Q0JTJ3 B4DHK0 A8K6W7 Q0JRZ9
|
| Accessions |
EAW95716 Q0JRZ9 AK291782 BAF84471 AK293796 BAG57208 AK295141 BAG58162 AL831971 AL832928 AL833313 AM393291 CAL38169 AM393840 CAL38715 BC006004 AAH06004 BC014311 AAH14311 BC137070 AAI37071 NM_001146032 NP_001139504 NM_138782 NP_620137
|
| Function |
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.
|
| Subcellular Location |
Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.
|