FCHO2

Gene Symbol FCHO2
Entrez Gene 115548
Alt Symbol -
Species Human
Gene Type protein-coding
Description FCH domain only 2
Other Description F-BAR domain only protein 2|FCH domain only protein 2
Swissprots E9PG79 B2RNQ9 Q96CF5 Q0JTJ3 B4DHK0 A8K6W7 Q0JRZ9
Accessions EAW95716 Q0JRZ9 AK291782 BAF84471 AK293796 BAG57208 AK295141 BAG58162 AL831971 AL832928 AL833313 AM393291 CAL38169 AM393840 CAL38715 BC006004 AAH06004 BC014311 AAH14311 BC137070 AAI37071 NM_001146032 NP_001139504 NM_138782 NP_620137
Function Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.
Subcellular Location Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.

Human-FCHO2-cDNA-Clone - DC03813 from Abgent, a WuXi AppTec company

Prices $507.60
Sizes 10 µg
Species Human
Accession BC014311

FCHO2 - MBS1274352 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC014311

Human FCHO2 ORF Clone (BC014311) - CDCS416811 from Creative biogene

Species Human
Accession Q0JRZ9
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