FCHO2

Gene Symbol FCHO2
Entrez Gene 115548
Alt Symbol -
Species Human
Gene Type protein-coding
Description FCH domain only 2
Other Description F-BAR domain only protein 2|FCH domain only protein 2
Swissprots E9PG79 B2RNQ9 Q96CF5 Q0JTJ3 B4DHK0 A8K6W7 Q0JRZ9
Accessions EAW95716 Q0JRZ9 AK291782 BAF84471 AK293796 BAG57208 AK295141 BAG58162 AL831971 AL832928 AL833313 AM393291 CAL38169 AM393840 CAL38715 BC006004 AAH06004 BC014311 AAH14311 BC137070 AAI37071 NM_001146032 NP_001139504 NM_138782 NP_620137
Function Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.
Subcellular Location Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.

FCHO2 CRISPR/Cas9 KO Plasmid (h) - sc-414071 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FCHO2 HDR Plasmid (h) - sc-414071-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FCHO2 Double Nickase Plasmid (h) - sc-414071-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FCHO2 Double Nickase Plasmid (h2) - sc-414071-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FCHO2 CRISPR Activation Plasmid (h) - sc-414071-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FCHO2 CRISPR Activation Plasmid (h2) - sc-414071-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FCHO2 Lentiviral Activation Particles (h) - sc-414071-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FCHO2 Lentiviral Activation Particles (h2) - sc-414071-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FCHO2 siRNA (h) - sc-91916 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FCHO2 shRNA Plasmid (h) - sc-91916-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FCHO2 shRNA (h) Lentiviral Particles - sc-91916-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU068491 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8596 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8596 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FCHO2 siRNA (Human) - CRJ4451 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FCHO2 - MBS8206168 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human FCHO2 siRNA - orb274952 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FCHO2 shRNA Plasmid (Human) - CHJ4451 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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