FCHO2

Gene Symbol FCHO2
Entrez Gene 115548
Alt Symbol -
Species Human
Gene Type protein-coding
Description FCH domain only 2
Other Description F-BAR domain only protein 2|FCH domain only protein 2
Swissprots E9PG79 B2RNQ9 Q96CF5 Q0JTJ3 B4DHK0 A8K6W7 Q0JRZ9
Accessions EAW95716 Q0JRZ9 AK291782 BAF84471 AK293796 BAG57208 AK295141 BAG58162 AL831971 AL832928 AL833313 AM393291 CAL38169 AM393840 CAL38715 BC006004 AAH06004 BC014311 AAH14311 BC137070 AAI37071 NM_001146032 NP_001139504 NM_138782 NP_620137
Function Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.
Subcellular Location Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.

Anti-FCHO2 antibody - ab139731 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of FCHO2 in Human heart tissue with ab139731 at 20 ug/mL.

Anti-FCHO2 antibody - ab122407 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122407, at a 1/40 dilution, staining FCHO2 in glandular cells of paraffin-embedded Human small intestine tissue by immunohistochemistry.

Anti-FCHO2 antibody - ab173771 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FCHO2 antibody (ab173771) at 1/100 dilution + Mouse lung tissue lysate at 35 µg

Anti-FCHO2 Antibody (aa137-165, AP) - LS-C235257 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FCHO2 Antibody (aa137-165, FITC) - LS-C235259 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FCHO2 Antibody (aa137-165, Biotin) - LS-C235260 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FCHO2 Antibody (aa137-165, APC) - LS-C235258 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FCHO2 Antibody (aa137-165, PE) - LS-C235262 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FCHO2 Antibody (aa137-165, Azide-free, HRP) - LS-C249981 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FCHO2 Antibody (aa136-165) - LS-C321342 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FCHO2 Antibody (aa73-122) - LS-C152198 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FCHO2 antibody Western Blot of HeLa.

Anti-FCHO2 Antibody (aa137-165) - LS-C159638 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FCHO2 Antibody western blot of mouse lung tissue lysates (35 ug/lane). The FCHO2 antibody detected the FCHO2 protein (arrow).

Anti-FCHO2 Antibody (aa150-200) - LS-C290076 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human FCHO2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from 293T (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), HeLa (H; 50 ug) and Jurkat (J; 50 ug) cells. Antibodies: Affinity purified rabbit anti-FCHO2 antibody used for WB at 0.04 ug/ml (A) and 0.4 ug/ml (B) and used for IP at 6 ug/mg lysate. FCHO2 was also immunoprecipitated by rabbit anti-FCHO2 antibody BL12144, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 60 seconds (A) and 10 seconds (B).

Anti-FCHO2 Antibody (Internal) - LS-C153704 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of FCHO2 in human heart tissue with FCHO2 antibody at 2.5 ug/ml.

FCHO2 Antibody - NBP2-32694 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FCHO2 Antibody [NBP2-32694] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4

FCHO2 Antibody - NBP1-90904 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: FCHO2 Antibody [NBP1-90904] - Staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.

FCHO2 Antibody - NBP2-16460 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FCHO2 Antibody [NBP2-16460] - Sample (30 ug of whole cell lysate) A: HCT116 7. 5% SDS PAGE gel, diluted at 1:1000.

FCHO2 Antibody - NBP2-36524 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FCHO2 Antibody [NBP2-36524] - Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-FCHO2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-FCHO2 antibody produced in rabbit - HPA037686 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FCHO2: <B>Cat. No. HPA037686</B>: Immunohistochemical staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.

ANTI-FCHO2 (CENTER) antibody produced in rabbit - SAB1304260 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-FCHO2 (Center): <B>Cat. No. SAB1304260</B>: FCHO2 Antibody (Center) western blot analysis in mouse lung tissue lysates (35 μg/lane).

Anti-FCHO2 (N-terminal) antibody produced in rabbit - SAB2700652 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FCHO2 (N-terminal): <B>Cat. No. SAB2700652</B>: Immunohistochemical analysis of paraffin-embedded H1299 xenograft, using FCHO2 antibody at 1:500 dilution.

Anti-FCHO2 antibody produced in rabbit - HPA037685 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FCHO2: <B>Cat. No. HPA037685</B>: Immunohistochemical staining of Human placenta shows strong membranous positivity in trophoblastic cells.

Anti-FCHO2 antibody produced in rabbit - SAB3500842 from Sigma-Aldrich

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>FCHO2 Antibody: <B>Cat. No. SAB3500842</B>: Western blot analysis of FCHO2 in Rat heart tissue lysate with FCHO2 antibody at (A) 1 and (B) 2 μg/mL.

FCHO2 Antibody - N-terminal region (ARP66570_P050) - ARP66570_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FCHO2-Antibody-Center - AP18034c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
FCHO2 Antibody (Center) (Cat. #AP18034c) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the FCHO2 antibody detected the FCHO2 protein (arrow).
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