| Gene Symbol | FCHO2 |
|---|---|
| Entrez Gene | 115548 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | FCH domain only 2 |
| Other Description | F-BAR domain only protein 2|FCH domain only protein 2 |
| Swissprots | E9PG79 B2RNQ9 Q96CF5 Q0JTJ3 B4DHK0 A8K6W7 Q0JRZ9 |
| Accessions | EAW95716 Q0JRZ9 AK291782 BAF84471 AK293796 BAG57208 AK295141 BAG58162 AL831971 AL832928 AL833313 AM393291 CAL38169 AM393840 CAL38715 BC006004 AAH06004 BC014311 AAH14311 BC137070 AAI37071 NM_001146032 NP_001139504 NM_138782 NP_620137 |
| Function | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150, ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. |
| Subcellular Location | Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}. |
FCHO2 Antibody Blocking Peptide - LS-E5512 from LifeSpan Bioscience
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FCHO2 Antibody Blocking Peptide - LS-E31277 from LifeSpan Bioscience
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FCHO2 Antibody Blocking Peptide - LS-E24163 from LifeSpan Bioscience
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FCHO2-Antibody-Center-Blocking-Peptide - BP18034c from Abgent, a WuXi AppTec company
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FCHO2 (Center) Control Peptide - AP55420CP-N from Acris Antibodies
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FCHO2 Peptide - 6871P from ProSci
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FCHO2 fusion protein - ag18556 from Proteintech Group
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Recombinant Human FCH domain only protein 2(FCHO2) ,partial - CSB-YP606615HU CSB-EP606615HU CSB-BP606615HU CSB-MP606615HU from Cusabio
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FCHO2 Recombinant Protein Antigen - NBP1-90904PEP from Novus Biologicals
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FCHO2 Recombinant Protein Antigen - NBP2-32694PEP from Novus Biologicals
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FCH domain only protein 2 (FCHO2), partial, Recombinant Protein - MBS1280424 from MyBioSource
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FCHO2 Recombinant Protein Antigen - NBP2-58027PEP from Novus Biologicals
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