SOCS1

Gene Symbol	SOCS1
Entrez Gene	8651
Alt Symbol	CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Species	Human
Gene Type	protein-coding
Description	suppressor of cytokine signaling 1
Other Description	JAK binding protein|JAK-binding protein|STAT induced SH3 protein 1|STAT-induced STAT inhibitor 1|TIP-3|Tec-interacting protein 3|cytokine-inducible SH2 protein 1
Swissprots	Q9NSA7 O15524 O15097
Accessions	AAD27709 AAY87931 CAB92528 CAR95151 CBX47480 EAW85163 O15524 AB000676 BAA21537 AB000734 BAA23521 AB005043 BAA22431 AK127621 BAG54535 BC029307 BC148542 AAI48543 BC153088 AAI53089 U88326 AAB62401 NM_003745 NP_003736
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. {ECO:0000250, ECO:0000269|PubMed:11278610, ECO:0000269|PubMed:11313480}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269|PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Tissue Specificity	Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Top Pathways	Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Toxoplasmosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SOCS1 ELISA Kit (Sandwich ELISA) - LS-F7983 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.313-20 ng/ml

Rat SOCS1 ELISA Kit (Sandwich ELISA) - LS-F8516 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 0.313-20 ng/ml

Rat SOCS1 ELISA Kit (Sandwich ELISA) - LS-F12628 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.313-20 ng/ml

Suppressor of cytokine signaling 1, SOCS1, Human, ELISA Kit - E1416h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Suppressors Of Cytokine Signaling 1 (SOCS1), Human, ELISA Kit - SEH158Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.109ng/mL Range 0.312-20ng/mL

Suppressors Of Cytokine Signaling 1 (SOCS1) - MBS9311380 from MyBioSource Category ELISA Kit

Suppressors Of Cytokine Signaling 1 (SOCS1), ELISA Kit - MBS2021770 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.125ng/mL. Range 0.313-20ng/mL

Suppressors Of Cytokine Signaling 1 (SOCS1), ELISA Kit - MBS2023410 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.115ng/mL. Range 0.313-20ng/mL

ELISA Kit for Suppressors Of Cytokine Signaling 1 (SOCS1) - SEH158Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.125ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Suppressors Of Cytokine Signaling 1 (SOCS1) - SEH158Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.115ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

CpG WIZ® SOCS1 - Methylation specific PCR assay - S7809 from EMD Millipore

ELISA Kit for Suppressors Of Cytokine Signaling 1 (SOCS1) - SEH158Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.125ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human SOCS1 ELISA Kit (Custom ELISA) - LS-F17175 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Mouse SOCS1 ELISA Kit (Custom ELISA) - LS-F17176 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Human SOCS1 ELISA Kit - abx153130 from Abbexa Category ELISA Kit Sensitivity 0.113 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human Suppressor of cytokine signaling 1 ELISA Kit - abx250862 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Suppressors Of Cytokine Signaling 1 (SOCS1), Human, ELISA Kit - DL-SOCS1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human SOCS1(Suppressor of Cytokine Signaling 1) ELISA Kit - E-EL-H2536 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Human SOCS1 ELISA Kit - orb369449 from Biorbyt Category ELISA Kit Prices $553.00, $621.00 Sizes 48 test, 96 test Range Detection Range: 0.313-20ng/mL Detection low threshold: 0.113ng/mL

Human SOCS1 ELISA Kit - abx572709 from Abbexa Category ELISA Kit Sensitivity 0.113 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human Suppressor of cytokine signaling 1 ELISA Kit - EKE53897 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.072 ng/mL Range 0.156-10 ng/mL

SOCS1 - EKH3144 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Human SOCS1 ELISA Kit - E036956 from Biobool Category ELISA Kit Sensitivity <0.094ng/ml

Human SOCS-1 ELISA Kit - E036983 from Biobool Category ELISA Kit

SOCS1 ELISA Kit (Human) (OKEH04855) - OKEH04855 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity < 0.07 ng/mL Range 0.156 - 10 ng/mL

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