SOCS1

Gene Symbol	SOCS1
Entrez Gene	8651
Alt Symbol	CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Species	Human
Gene Type	protein-coding
Description	suppressor of cytokine signaling 1
Other Description	JAK binding protein|JAK-binding protein|STAT induced SH3 protein 1|STAT-induced STAT inhibitor 1|TIP-3|Tec-interacting protein 3|cytokine-inducible SH2 protein 1
Swissprots	Q9NSA7 O15524 O15097
Accessions	AAD27709 AAY87931 CAB92528 CAR95151 CBX47480 EAW85163 O15524 AB000676 BAA21537 AB000734 BAA23521 AB005043 BAA22431 AK127621 BAG54535 BC029307 BC148542 AAI48543 BC153088 AAI53089 U88326 AAB62401 NM_003745 NP_003736
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. {ECO:0000250, ECO:0000269|PubMed:11278610, ECO:0000269|PubMed:11313480}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269|PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Tissue Specificity	Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Top Pathways	Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Toxoplasmosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SOCS1 cDNA clone(NM_003745.1) - CDFH018305 from Creative Biomart Species Human Accession NM_003745.1

Human SOCS1 ORF Clone(NM_003745.1) - CDCR286376 from Creative Biomart Species Human Accession NM_003745.1

Human SOCS1 ORF Clone(NM_003745.1) - CDCR286377 from Creative Biomart Species Human Accession NM_003745.1

Human SOCS1 ORF Clone(NM_003745.1) - CDCR286378 from Creative Biomart Species Human Accession NM_003745.1

human SOCS1 ORF clone - CDCH084366 from Creative Biomart Species Human Accession NM_003745

human SOCS1 ORF clone - CDCH084367 from Creative Biomart Species Human Accession NM_003745

Human SOCS1 ORF Clone(NM_003745.1) - CDCL176636 from Creative Biomart Species Human Accession NM_003745.1

Human SOCS1 Gene cDNA Clone (full-length ORF Clone) - HG13318-G from Sino Biological Species Human Accession NM_003745.1

Human SOCS1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13318-ANG from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid - HG13318-UT from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13318-CY from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13318-NF from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13318-NM from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13318-CF from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid, N-His tag - HG13318-NH from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13318-CM from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13318-NY from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13318-ACR from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13318-ANR from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid, C-His tag - HG13318-CH from Sino Biological Species Human

Human SOCS1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13318-ACG from Sino Biological Species Human

human SOCS1 ORF clone (NM_003745.1) - CDCH084366 from Creative biogene Species Human

Human SOCS1 cDNA Clone(NM_003745.1) - CDFH018305 from Creative biogene Species Human

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