| Gene Symbol | SOCS1 |
|---|---|
| Entrez Gene | 8651 |
| Alt Symbol | CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | suppressor of cytokine signaling 1 |
| Other Description | JAK binding protein|JAK-binding protein|STAT induced SH3 protein 1|STAT-induced STAT inhibitor 1|TIP-3|Tec-interacting protein 3|cytokine-inducible SH2 protein 1 |
| Swissprots | Q9NSA7 O15524 O15097 |
| Accessions | AAD27709 AAY87931 CAB92528 CAR95151 CBX47480 EAW85163 O15524 AB000676 BAA21537 AB000734 BAA23521 AB005043 BAA22431 AK127621 BAG54535 BC029307 BC148542 AAI48543 BC153088 AAI53089 U88326 AAB62401 NM_003745 NP_003736 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. {ECO:0000250, ECO:0000269|PubMed:11278610, ECO:0000269|PubMed:11313480}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269|PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3. |
| Tissue Specificity | Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes. |
| Top Pathways | Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Toxoplasmosis |
SOCS-1 CRISPR/Cas9 KO Plasmid (h) - sc-400618 from Santa Cruz Biotechnology
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SOCS-1 HDR Plasmid (h) - sc-400618-HDR from Santa Cruz Biotechnology
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SOCS-1 Double Nickase Plasmid (h) - sc-400618-NIC from Santa Cruz Biotechnology
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SOCS-1 Double Nickase Plasmid (h2) - sc-400618-NIC-2 from Santa Cruz Biotechnology
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SOCS-1 CRISPR Activation Plasmid (h) - sc-400618-ACT from Santa Cruz Biotechnology
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SOCS-1 CRISPR Activation Plasmid (h2) - sc-400618-ACT-2 from Santa Cruz Biotechnology
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SOCS-1 Lentiviral Activation Particles (h) - sc-400618-LAC from Santa Cruz Biotechnology
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SOCS-1 Lentiviral Activation Particles (h2) - sc-400618-LAC-2 from Santa Cruz Biotechnology
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SOCS-1 siRNA (h) - sc-40996 from Santa Cruz Biotechnology
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SOCS-1 shRNA Plasmid (h) - sc-40996-SH from Santa Cruz Biotechnology
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SOCS-1 shRNA (h) Lentiviral Particles - sc-40996-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN20320 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20320 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03468 from Sigma-Aldrich
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SOCS1 siRNA (Human) - CRH5689 from Cohesion Biosciences
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SOCS1 - MBS8238395 from MyBioSource
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SOCS-1 CRISPR/Cas9 KO Plasmid (h2) - sc-400618-KO-2 from Santa Cruz Biotechnology
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SOCS-1 HDR Plasmid (h2) - sc-400618-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human SOCS1(NM_003745.1) - SHL024222 from Creative biogene
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Human SOCS1 siRNA - orb266191 from Biorbyt
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SOCS1 shRNA Plasmid (Human) - CHH5689 from Cohesion Biosciences
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SOCS1 miRNA 3'UTR clone - MiUTR1H-09730 from Creative biogene
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