SOCS1

Gene Symbol	SOCS1
Entrez Gene	8651
Alt Symbol	CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Species	Human
Gene Type	protein-coding
Description	suppressor of cytokine signaling 1
Other Description	JAK binding protein|JAK-binding protein|STAT induced SH3 protein 1|STAT-induced STAT inhibitor 1|TIP-3|Tec-interacting protein 3|cytokine-inducible SH2 protein 1
Swissprots	Q9NSA7 O15524 O15097
Accessions	AAD27709 AAY87931 CAB92528 CAR95151 CBX47480 EAW85163 O15524 AB000676 BAA21537 AB000734 BAA23521 AB005043 BAA22431 AK127621 BAG54535 BC029307 BC148542 AAI48543 BC153088 AAI53089 U88326 AAB62401 NM_003745 NP_003736
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. {ECO:0000250, ECO:0000269|PubMed:11278610, ECO:0000269|PubMed:11313480}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269|PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Tissue Specificity	Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Top Pathways	Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Toxoplasmosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SOCS1 peptide - ab39852 from Abcam Category Peptide Species Human

Human SOCS1 peptide - ab88167 from Abcam Category Peptide

Human SOCS1 peptide - ab23167 from Abcam Category Peptide Species Human

SOCS1 Antibody Blocking Peptide - LS-E30222 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SOCS1 Antibody Blocking Peptide - LS-E30223 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SOCS1 Antibody Blocking Peptide - LS-E25203 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SOCS1 Antibody Blocking Peptide - LS-E9783 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SOCS1 Antibody Blocking Peptide - LS-E15509 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SOCS-1 Peptide - NBP1-76415PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

SOCS-1 Peptide - NBP1-76416PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

SOCS1-Antibody-N-term-Blocking-Peptide - BP8790a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SOCS1 blocking peptide - GTX89995-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Human SOCS1 protein - orb244555 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human SOCS1 protein - orb245997 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

SOCS1 Peptide - orb224245 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

SOCS1 Blocking Peptide - 33R-10964 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

SOCS1 Blocking Peptide - 33R-10561 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

SOCS1 Blocking Peptide - 33R-8127 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SOCS1 Blocking Peptide - 33R-8152 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SOCS1 Peptide - AC21-0024-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SOCS1 Control Peptide - AP10327CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

SOCS1 Control Peptide - AP30817CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SOCS1 Control Peptide - AP30818CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SOCS1 Peptide - 3767P from ProSci Category Peptide Species Human

SOCS1 Peptide - 46-408P from ProSci Category Peptide Species Mouse, Human

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