SOCS1

Gene Symbol SOCS1
Entrez Gene 8651
Alt Symbol CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Species Human
Gene Type protein-coding
Description suppressor of cytokine signaling 1
Other Description JAK binding protein|JAK-binding protein|STAT induced SH3 protein 1|STAT-induced STAT inhibitor 1|TIP-3|Tec-interacting protein 3|cytokine-inducible SH2 protein 1
Swissprots Q9NSA7 O15524 O15097
Accessions AAD27709 AAY87931 CAB92528 CAR95151 CBX47480 EAW85163 O15524 AB000676 BAA21537 AB000734 BAA23521 AB005043 BAA22431 AK127621 BAG54535 BC029307 BC148542 AAI48543 BC153088 AAI53089 U88326 AAB62401 NM_003745 NP_003736
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. {ECO:0000250, ECO:0000269|PubMed:11278610, ECO:0000269|PubMed:11313480}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269|PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Tissue Specificity Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Top Pathways Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Toxoplasmosis

SOCS1 (A156) Antibody - 3950 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from BaF3 cells starved of mouse IL-3 and serum overnight, untreated (-) or mouse IL-3-treated (10 ng/ml, 6 hr; +) and NK-92 cells starved of human IL-2 and serum overnight, untreated (-) or human IL-2-treated (10 ng/ml, 6 hr; +), using SOCS1 (A156) Antibody.

SOCS1 (P50) Antibody - 3957 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

SOCS-1 (H-93) - sc-9021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SOCS-1 (H-93): sc-9021. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of trophoblastic cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

SOCS-1 (N-18) - sc-7006 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SOCS-1 (N-18): sc-7006. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing cytoplasmic and perinuclear staining of glandular cells.

Anti-SOCS1 antibody - ab137384 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SOCS1 antibody (ab137384) at 1/1000 dilution + Hep G2 whole cell lysate at 30 µg

Anti-SOCS1 antibody - ab9870 from Abcam

Prices $400.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab9870 (2.5µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-SOCS1 antibody - ab62584 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-SOCS1 antibody (ab62584) at 1 µg/mlLane 2 : Anti-SOCS1 antibody (ab62584) at 2 µg/mlLane 3 : Anti-SOCS1 antibody (ab62584) at 4 µg/mlLane 1 : Human spleen cell lysateLane 2 : Human spleen cell lysateLane 3 : Human spleen cell lysateLysates/proteins at 15 µg per lane.

Anti-SOCS1 antibody - ab83493 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SOCS1 antibody (ab83493) at 1/500 dilutionLane 1 : Tissue /cell lysate derived from mouse liver.Lane 2 : Tissue /cell lysate derived from mouse muscle.Lane 3 : MCF7.

Anti-SOCS1 antibody - ab77072 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of SOCS1 staining in Rat Spleen formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab77072, 1 µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, pri

Anti-SOCS1 antibody - ab37167 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-SOCS1 antibody (ab37167) at 1 µg/mlLane 2 : Anti-SOCS1 antibody (ab37167) at 2 µg/mlLane 3 : Anti-SOCS1 antibody (ab37167) at 4 µg/mlLane 1 : Human spleen cell lysateLane 2 : Human spleen cell lysateLane 3 : Human spleen cell lysateLysates/proteins at 15 µg per lane.Secondarygoat anti-rabbit HRP at 1/10000 dilution

Anti-SOCS1 antibody - Carboxyterminal end - ab65989 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab65989, at 0.5µg/ml, staining SOCS1 in paraffin-embedded rat lung tissue by immunohistochemistry. Staining of SOCS1 in the nucleus is observed. DAB chromogenic reaction.

Anti-SOCS1 antibody - N-terminal - ab135718 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of SOCS1 expression in WiDr cells labelled with ab135718 at 1/10 dilution (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Anti-SOCS1 Antibody - LS-C10262 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS1 Antibody (N-Terminus, clone 4H1) - LS-C10263 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4H1

Anti-SOCS1 Antibody (C-Terminus) - LS-C10265 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS1 Antibody (N-Terminus) - LS-C10266 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS1 Antibody - LS-C808 from LifeSpan Bioscience

Prices $335.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot of SOCS1 using antibody at 1:1000 dilution against 15 ug/lane of Ramos (A) and Raw (B) cell lysate.

Anti-SOCS1 Antibody (C-Terminus) - LS-C122433 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS1 Antibody - LS-C146997 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS1 Antibody (C-Terminus, Magnetic beads) - LS-C171845 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS1 Antibody (Val98) - LS-C177570 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS1 Antibody (C-Terminus, Sepharose) - LS-C171846 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS1 Antibody (aa21-70) - LS-C31894 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
SOCS1 antibody LS-C31894 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-SOCS1 Antibody (clone 4H1, Biotin) - LS-C179704 from LifeSpan Bioscience

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4H1

Anti-SOCS1 Antibody (C-Terminus) - LS-C189200 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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