Vhl

Gene Symbol Vhl
Entrez Gene 22346
Alt Symbol Vhlh
Species Mouse
Gene Type protein-coding
Description von Hippel-Lindau tumor suppressor
Other Description pVHL|von Hippel-Lindau disease tumor suppressor|von Hippel-Lindau syndrome homolog|von Hippel-Lindau syndrome protein homolog
Swissprots P40338
Accessions AAM53645 EDK99490 EDK99491 P40338 AK159238 BAE34921 AK161408 BAE36378 AK171264 BAE42352 AK171604 BAE42557 BC052417 AAH52417 S76748 AAB33363 U12570 AAA20662 NM_009507 NP_033533
Function Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ADRB2 at the cell membrane. {ECO:0000250}.
Top Pathways Ubiquitin mediated proteolysis, Renal cell carcinoma

VHL (D-7) - sc-55506 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VHL (D-7): sc-55506. Western blot analysis of VHL expression in F9 whole cell lysate.

VHL (G-3) - sc-514041 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VHL (G-3): sc-514041. Western blot analysis of VHL expression in mouse testis (A), mouse brain (B) and mouse lung (C) tissue extracts and F9 (D) and RAW 264.7 (E) whole cell lysates.

VHL (M-20) - sc-1534 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VHL (M-20): sc-1534. Western blot analysis of VHL expression in mouse brain (A) and mouse testis (B) tissue extracts.

VHL (R-20) - sc-1535 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VHL (R-20): sc-1535. Western blot analysis of VHL expression in 3611-RF (A) and KNRK (B) nuclear extracts.

VHL antibody - 70R-34605 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VHL antibody - STJ70964 from St John's Laboratory Ltd

Host Goat
Clonality Polyclonal

Caspase-2 (clone 1C10), Antibody - GWB-BAC0D9 from Genway Biotech

Prices $185.00, $310.00
Sizes 50 μl, 100 μl
Host Mouse
Clonality Monoclonal
Clone Anti-human Caspase-2 mAb, clone 1C10, is deri

VHL Antibody - TGB-752 from Reagent Proteins

Prices $348.00, $675.00
Sizes 20.00 µg, 100.00 µg
Host Mouse
Clonality Monoclonal

VHL (B-9) - sc-514959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

VHL (D-11) - sc-514907 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VHL (D-11): sc-514907. Western blot analysis of VHL expression in 3611-RF (A) and KNRK (B) nuclear extracts, F9 whole cell lysate (C) and rat testis (D), rat brain (E) and mouse brain (F) tissue extracts.

anti-VHL antibody - ARG64033 from Arigo Biolaboratories

ARG64033 anti-VHL antibody WB image Western Blot: Human Ovary lysate (35 µg protein in RIPA buffer) stained with ARG64033 anti-VHL antibody at 0.01 µg/ml dilution.

VHL Polyclonal Antibody - A11240 from ARP American Research Products

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Clonality Polyclonal
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