| Gene Symbol | Vhl |
|---|---|
| Entrez Gene | 22346 |
| Alt Symbol | Vhlh |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | von Hippel-Lindau tumor suppressor |
| Other Description | pVHL|von Hippel-Lindau disease tumor suppressor|von Hippel-Lindau syndrome homolog|von Hippel-Lindau syndrome protein homolog |
| Swissprots | P40338 |
| Accessions | AAM53645 EDK99490 EDK99491 P40338 AK159238 BAE34921 AK161408 BAE36378 AK171264 BAE42352 AK171604 BAE42557 BC052417 AAH52417 S76748 AAB33363 U12570 AAA20662 NM_009507 NP_033533 |
| Function | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ADRB2 at the cell membrane. {ECO:0000250}. |
| Top Pathways | Ubiquitin mediated proteolysis, Renal cell carcinoma |
Von Hippel-Lindau disease tumor suppressor, Vhl, Mouse, ELISA Kit - E1894m from ARP American Research Products
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von Hippel-Lindau tumor suppressor, ELISA Kit - MBS9328482 from MyBioSource
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Mouse Vhl ELISA Kit - E072610 from Biobool
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VHL ELISA Kit (Mouse) (OKEH05306) - OKEH05306 from Aviva Systems Biology
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Von Hippel-Lindau disease tumor suppressor, ELISA Kit - MBS2885931 from MyBioSource
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