Vhl

Gene Symbol Vhl
Entrez Gene 22346
Alt Symbol Vhlh
Species Mouse
Gene Type protein-coding
Description von Hippel-Lindau tumor suppressor
Other Description pVHL|von Hippel-Lindau disease tumor suppressor|von Hippel-Lindau syndrome homolog|von Hippel-Lindau syndrome protein homolog
Swissprots P40338
Accessions AAM53645 EDK99490 EDK99491 P40338 AK159238 BAE34921 AK161408 BAE36378 AK171264 BAE42352 AK171604 BAE42557 BC052417 AAH52417 S76748 AAB33363 U12570 AAA20662 NM_009507 NP_033533
Function Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ADRB2 at the cell membrane. {ECO:0000250}.
Top Pathways Ubiquitin mediated proteolysis, Renal cell carcinoma

Recombinant Mouse Von Hippel-Lindau disease tumor suppressor(Vhl) - CSB-YP025852MO CSB-EP025852MO CSB-BP025852MO CSB-MP025852MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Von Hippel-Lindau disease tumor suppressor (Vhl) , Recombinant Protein - MBS964006 from MyBioSource

Category Protein
Prices $1,380.00, $1,380.00, $1,835.00, $1,835.00
Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Recombinant Mouse VHL Protein - VHL-18015M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse
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