Vhl

Gene Symbol	Vhl
Entrez Gene	22346
Alt Symbol	Vhlh
Species	Mouse
Gene Type	protein-coding
Description	von Hippel-Lindau tumor suppressor
Other Description	pVHL|von Hippel-Lindau disease tumor suppressor|von Hippel-Lindau syndrome homolog|von Hippel-Lindau syndrome protein homolog
Swissprots	P40338
Accessions	AAM53645 EDK99490 EDK99491 P40338 AK159238 BAE34921 AK161408 BAE36378 AK171264 BAE42352 AK171604 BAE42557 BC052417 AAH52417 S76748 AAB33363 U12570 AAA20662 NM_009507 NP_033533
Function	Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ADRB2 at the cell membrane. {ECO:0000250}.
Top Pathways	Ubiquitin mediated proteolysis, Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse Vhlh ORF clone (NM_009507.3) - CDCH099470 from Creative biogene Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, C-Flag tag - MG57368-CF from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - MG57368-ANR from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - MG57368-ACR from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone in cloning vector - MG57368-U from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, C-His tag - MG57368-CH from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, C-Myc tag - MG57368-CM from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, N-Flag tag - MG57368-NF from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - MG57368-ACG from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, N-His tag - MG57368-NH from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, C-HA tag - MG57368-CY from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, N-Myc tag - MG57368-NM from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid - MG57368-UT from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - MG57368-ANG from Sino Biological Species Mouse

Mouse VHL Gene ORF cDNA clone expression plasmid, N-HA tag - MG57368-NY from Sino Biological Species Mouse

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