Vhl

Gene Symbol Vhl
Entrez Gene 22346
Alt Symbol Vhlh
Species Mouse
Gene Type protein-coding
Description von Hippel-Lindau tumor suppressor
Other Description pVHL|von Hippel-Lindau disease tumor suppressor|von Hippel-Lindau syndrome homolog|von Hippel-Lindau syndrome protein homolog
Swissprots P40338
Accessions AAM53645 EDK99490 EDK99491 P40338 AK159238 BAE34921 AK161408 BAE36378 AK171264 BAE42352 AK171604 BAE42557 BC052417 AAH52417 S76748 AAB33363 U12570 AAA20662 NM_009507 NP_033533
Function Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ADRB2 at the cell membrane. {ECO:0000250}.
Top Pathways Ubiquitin mediated proteolysis, Renal cell carcinoma

VHL CRISPR/Cas9 KO Plasmid (m) - sc-423671 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VHL HDR Plasmid (m) - sc-423671-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VHL Double Nickase Plasmid (m) - sc-423671-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VHL Double Nickase Plasmid (m2) - sc-423671-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VHL CRISPR Activation Plasmid (m) - sc-423671-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VHL CRISPR Activation Plasmid (m2) - sc-423671-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VHL Lentiviral Activation Particles (m) - sc-423671-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VHL Lentiviral Activation Particles (m2) - sc-423671-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VHL siRNA (m) - sc-36817 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

VHL shRNA Plasmid (m) - sc-36817-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

VHL shRNA (m) Lentiviral Particles - sc-36817-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU012571 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN44114 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND44114 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

VHL siRNA (Mouse) - CRM4390 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

VHL - MBS8214518 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

VHL CRISPR/Cas9 KO Plasmid (m2) - sc-423671-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

VHL HDR Plasmid (m2) - sc-423671-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

shRNA set against Mouse VHL (NM_009507.3) - SHH442720 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Vhlh(NM_009507.3) - SHL125654 from Creative biogene

Category siRNA
Species Reactivities Mouse

VHL shRNA Plasmid (Mouse) - CHM4390 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

VHL miRNA 3'UTR clone - MiUTR1M-12685 from Creative biogene

Species Reactivities Mouse
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