NLGN1

Gene Symbol	NLGN1
Entrez Gene	22871
Alt Symbol	NL1
Species	Human
Gene Type	protein-coding
Description	neuroligin 1
Other Description	neuroligin-1
Swissprots	Q9UPT2 Q8N2Q7
Accessions	EAW78453 EAW78454 EAW78455 EAW78456 Q8N2Q7 AB028993 BAA83022 AF086015 AK074522 BAC11039 AK129874 AK307813 BC032555 AAH32555 CB052838 DA310134 DQ891239 ABM82165 EU176566 ABW03367 GQ489206 ADB12633 XM_005247232 XP_005247289 XM_005247233 XP_005247290 XM_005247234 XP_005247291 XM_005247235 XP_005247292 XM_005247236 XP_005247293 XM_005247237 XP_005247294 XM_006713540 XP_006713603 XM_011512551 XP_011510853 XM_011512552 XP_011510854 XM_011512553 XP_011510855 XM_011512554 XP_011510856 XM_011512555 XP_011510857 NM_014932 NP_055747
Function	Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. {ECO:0000250|UniProtKB:Q99K10}.
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1 (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

neuroligin 1 (A-4) - sc-365110 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

neuroligin 1 (F-5) - sc-365111 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

neuroligin 1 (F-7) - sc-365087 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

neuroligin 1 (H-45) - sc-50393 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

neuroligin 1 (K-16) - sc-14084 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

neuroligin 1 (L-20) - sc-14082 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Neuroligin 1 antibody - ab153821 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Neuroligin 1 antibody - ab172406 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Neuroligin 1 antibody - ab56882 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-Neuroligin 1 antibody - ab36131 from Abcam Prices $368.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-Neuroligin 1 antibody [S97A-31] - C-terminal (FITC) - ab186252 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S97A-31

Anti-Neuroligin 1 antibody [S97A-31] - C-terminal (HRP) - ab186289 from Abcam Prices $372.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S97A-31

Anti-Neuroligin 1 antibody - Synaptic Marker - ab26305 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NLGN1 + NLGN2 antibody - ab105170 from Abcam Host Rabbit Clonality Polyclonal

Anti-NLGN1 / Neuroligin 1 Antibody (aa669-678) - LS-C47563 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-NLGN1 / Neuroligin 1 Antibody (aa718-843, clone S97A-31) - LS-C209619 from LifeSpan Bioscience Prices $365.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S97A-31

Anti-NLGN1 / Neuroligin 1 Antibody - LS-C122199 from LifeSpan Bioscience Prices $515.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-NLGN1 / Neuroligin 1 Antibody (aa718-843, clone S97A-31, Atto 488) - LS-C230363 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S97A-31

Anti-NLGN1 / Neuroligin 1 Antibody (C-Terminus) - LS-C73277 from LifeSpan Bioscience Prices $560.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NLGN1 / Neuroligin 1 Antibody (aa718-843, clone S97A-31, Atto 565) - LS-C230366 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S97A-31

Anti-NLGN1 / Neuroligin 1 Antibody (aa718-843, clone S97A-31, Atto 390) - LS-C230364 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S97A-31

Anti-NLGN1 / Neuroligin 1 Antibody (aa718-843, clone S97A-31, Atto 594) - LS-C230368 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S97A-31

Anti-NLGN1 / Neuroligin 1 Antibody (aa718-843, clone S97A-31, Atto 680) - LS-C230371 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S97A-31

Anti-NLGN1 / Neuroligin 1 Antibody (aa718-843, clone S97A-31, Atto 655) - LS-C230370 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S97A-31

Anti-NLGN1 / Neuroligin 1 Antibody (aa718-843, clone S97A-31, Atto 633) - LS-C230369 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S97A-31

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