NLGN1

Gene Symbol	NLGN1
Entrez Gene	22871
Alt Symbol	NL1
Species	Human
Gene Type	protein-coding
Description	neuroligin 1
Other Description	neuroligin-1
Swissprots	Q9UPT2 Q8N2Q7
Accessions	EAW78453 EAW78454 EAW78455 EAW78456 Q8N2Q7 AB028993 BAA83022 AF086015 AK074522 BAC11039 AK129874 AK307813 BC032555 AAH32555 CB052838 DA310134 DQ891239 ABM82165 EU176566 ABW03367 GQ489206 ADB12633 XM_005247232 XP_005247289 XM_005247233 XP_005247290 XM_005247234 XP_005247291 XM_005247235 XP_005247292 XM_005247236 XP_005247293 XM_005247237 XP_005247294 XM_006713540 XP_006713603 XM_011512551 XP_011510853 XM_011512552 XP_011510854 XM_011512553 XP_011510855 XM_011512554 XP_011510856 XM_011512555 XP_011510857 NM_014932 NP_055747
Function	Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. {ECO:0000250|UniProtKB:Q99K10}.
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1 (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Neuroligin 1 full length protein - ab132182 from Abcam Category Protein Source Wheat germ Species Human

Human Neuroligin 1 peptide - ab27813 from Abcam Category Peptide

Human Neuroligin 1 protein fragment - ab161450 from Abcam Category Protein Source Wheat germ Species Human

Neuroligin 1 peptide (669-678) - ab45792 from Abcam Category Peptide Species Human

Neuroligin 1 protein fragment - ab151648 from Abcam Category Protein Source HEK 293 cells

NLGN1 / Neuroligin 1 Antibody Blocking Peptide - LS-E25920 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Neuroligin 1/NLGN1 Protein - H00022871-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Neuroligin 1/NLGN1 Protein - H00022871-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Neuroligin 1 blocking peptide - GTX89514-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Recombinant Rat Neuroligin 1/NLGN1, CF - 4340-NL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Met1-Leu676, with a C-terminal 6-His tag

Recombinant Human Neuroligin 1v2 (-ssB)/NLGN1v2 (-ssB), CF - 6446-NL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln46-Ser677, Deletion: aa 279-287, with a C-terminal 6-His tag

Recombinant Human Neuroligin 1v2/NLGN1v2, CF - 7066-NL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Met1-Ser677, with a C-terminal 6-His tag

Human Neuroligin 1 protein - orb49554 from Biorbyt Category Protein Prices $255.00, $502.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human NLGN1 His tag protein - orb83987 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Neuroligin 1 Blocking Peptide - abx161178 from Abbexa Category Peptide Species Human, Mouse, Rat

Neuroligin 1 Peptide - AC21-0750-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Neuroligin 1 - H00022871-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Neuroligin 1 - H00022871-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Neuroligin 1 - H00022871-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Neuroligin 1 - H00022871-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Neuroligin-1, Human, Recombinant - 19-C493 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source HEK293 Species Human

Neuroligin 1 Peptide - 45-957P from ProSci Category Peptide

NLGN1 fusion protein - ag6356 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NLGN1 fusion protein - ag4583 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Neuroligin 1 Protein - BP001195-C493 from Syd Labs Category Protein Prices $98.00, $264.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

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