NLGN1
| Gene Symbol | NLGN1 |
|---|---|
| Entrez Gene | 22871 |
| Alt Symbol | NL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | neuroligin 1 |
| Other Description | neuroligin-1 |
| Swissprots | Q9UPT2 Q8N2Q7 |
| Accessions | EAW78453 EAW78454 EAW78455 EAW78456 Q8N2Q7 AB028993 BAA83022 AF086015 AK074522 BAC11039 AK129874 AK307813 BC032555 AAH32555 CB052838 DA310134 DQ891239 ABM82165 EU176566 ABW03367 GQ489206 ADB12633 XM_005247232 XP_005247289 XM_005247233 XP_005247290 XM_005247234 XP_005247291 XM_005247235 XP_005247292 XM_005247236 XP_005247293 XM_005247237 XP_005247294 XM_006713540 XP_006713603 XM_011512551 XP_011510853 XM_011512552 XP_011510854 XM_011512553 XP_011510855 XM_011512554 XP_011510856 XM_011512555 XP_011510857 NM_014932 NP_055747 |
| Function | Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. {ECO:0000250|UniProtKB:Q99K10}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1 (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856}. |
| Top Pathways | Cell adhesion molecules (CAMs) |
neuroligin 1 CRISPR/Cas9 KO Plasmid (h) - sc-401668 from Santa Cruz Biotechnology
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neuroligin 1 HDR Plasmid (h) - sc-401668-HDR from Santa Cruz Biotechnology
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neuroligin 1 Double Nickase Plasmid (h) - sc-401668-NIC from Santa Cruz Biotechnology
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neuroligin 1 Double Nickase Plasmid (h2) - sc-401668-NIC-2 from Santa Cruz Biotechnology
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neuroligin 1 CRISPR Activation Plasmid (h) - sc-401668-ACT from Santa Cruz Biotechnology
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neuroligin 1 CRISPR Activation Plasmid (h2) - sc-401668-ACT-2 from Santa Cruz Biotechnology
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neuroligin 1 Lentiviral Activation Particles (h) - sc-401668-LAC from Santa Cruz Biotechnology
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neuroligin 1 Lentiviral Activation Particles (h2) - sc-401668-LAC-2 from Santa Cruz Biotechnology
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neuroligin 1 siRNA (h) - sc-42083 from Santa Cruz Biotechnology
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neuroligin 1 shRNA Plasmid (h) - sc-42083-SH from Santa Cruz Biotechnology
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neuroligin 1 shRNA (h) Lentiviral Particles - sc-42083-V from Santa Cruz Biotechnology
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Neuroligin 1/NLGN1 RNAi - H00022871-R01 from Novus Biologicals
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MISSION® esiRNA - EHU152031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15342 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15342 from Sigma-Aldrich
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NLGN1 siRNA (Human) - CRH7828 from Cohesion Biosciences
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shRNA set against Human NLGN1 (NM_014932.2) - SHH352792 from Creative biogene
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shRNA set against Human NLGN1(NM_014932.2) - SHR012324 from Creative biogene
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Human NLGN1 siRNA - orb268330 from Biorbyt
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NLGN1 shRNA Plasmid (Human) - CHH7828 from Cohesion Biosciences
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NLGN1 miRNA 3'UTR clone - MiUTR1H-06787 from Creative biogene
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