NLGN1

Gene Symbol	NLGN1
Entrez Gene	22871
Alt Symbol	NL1
Species	Human
Gene Type	protein-coding
Description	neuroligin 1
Other Description	neuroligin-1
Swissprots	Q9UPT2 Q8N2Q7
Accessions	EAW78453 EAW78454 EAW78455 EAW78456 Q8N2Q7 AB028993 BAA83022 AF086015 AK074522 BAC11039 AK129874 AK307813 BC032555 AAH32555 CB052838 DA310134 DQ891239 ABM82165 EU176566 ABW03367 GQ489206 ADB12633 XM_005247232 XP_005247289 XM_005247233 XP_005247290 XM_005247234 XP_005247291 XM_005247235 XP_005247292 XM_005247236 XP_005247293 XM_005247237 XP_005247294 XM_006713540 XP_006713603 XM_011512551 XP_011510853 XM_011512552 XP_011510854 XM_011512553 XP_011510855 XM_011512554 XP_011510856 XM_011512555 XP_011510857 NM_014932 NP_055747
Function	Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. {ECO:0000250|UniProtKB:Q99K10}.
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1 (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NLGN1 293T Cell Transient Overexpression Lysate(Denatured) - H00022871-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

NLGN1 overexpression lysate - LY402393 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

neuroligin 1 (h): 293T Lysate - sc-115314 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Human Neuroligin 1 / NLGN1 HEK293 Cell Lysate (WB positive control) - 11617-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Neuroligin 1/NLGN1 Overexpression Lysate (Native) - NBP2-04347 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Neuroligin 1/NLGN1 Overexpression Lysate (Denatured) - H00022871-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human NLGN1 Human Cells Transfected Lysate (positive control) (denatured) - orb173576 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human NLGN1 Knockdown Stable Cell Line - CSC-DC010422 from Creative biogene Category Cell Line Species Human

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