PRKCQ

Gene Symbol PRKCQ
Entrez Gene 5588
Alt Symbol PRKCT, nPKC-theta
Species Human
Gene Type protein-coding
Description protein kinase C, theta
Other Description protein kinase C theta type
Swissprots Q64FY5 Q3MJF1 Q14DH6 Q9H508 B4DF52 Q9H549 Q04759
Accessions EAW86392 EAW86393 EAW86394 Q04759 AA234440 AI570478 AK293935 BAG57313 AK308099 AK312411 AU099414 AY702977 AAU29340 BC101465 AAI01466 BC113359 AAI13360 BC143222 BF592799 BX647657 HQ258485 ADR83239 L01087 AAA75571 L07032 AAA60101 R40214 XM_005252496 XP_005252553 XM_005252497 XP_005252554 XM_006717465 XP_006717528 XM_011519547 XP_011517849 XM_011519548 XP_011517850 NM_001242413 NP_001229342 NM_001282644 NP_001269573 NM_001282645 NP_001269574 NM_006257 NP_006248
Function Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non- canonical NF-kappa-B (NFKB2) pathway. In the signaling p
Subcellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.
Tissue Specificity Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets. {ECO:0000269|PubMed:7686153}.
Top Pathways Tight junction, T cell receptor signaling pathway, Adipocytokine signaling pathway, Vascular smooth muscle contraction, Measles

HTScan® PKCθ Kinase Assay Kit - 7606 from Cell Signaling Technology

Category Assay Kit
Figure 1. PKCtheta kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 5 mM MgCl2, 1.32 mM CaCl2, 1 mM EDTA, 1.25 mM EGTA, 0.25 μg/50 μl Phosphatidylserine, 50 ng/50 μl 1.2 Dioleyl-glycerol, 1.2 mM DTT, ATP (variable), 2.5 μg/50 μl PEG 20.000, Substrate: Histone H2B, 2 μg/50 μl and recombinant PKCtheta: 200 ng/50 µl.

Human Phospho-PRKCQ / PKC-Theta (Ser695) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1304 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-PRKCQ / PKC-Theta (Thr538) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1276 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-PRKCQ / PKC-Theta (Ser676) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1604 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat PRKCQ / PKC-Theta ELISA Kit (Cell-Based ELISA) - LS-F2252 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Protein Kinase C Theta, ELISA Kit - MBS081675 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS041750 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS751385 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta - MBS752419 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00
Sizes 48 strip wells, 96 strip wells

Protein Kinase C Theta, ELISA Kit - MBS012335 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS019256 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS044601 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS753212 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 pg/mL.

Protein Kinase C Theta, ELISA Kit - MBS725568 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS727892 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS729190 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS028026 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS017278 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS018311 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS093836 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS017556 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1ng/ml.
Range 0.5ng/ml-16ng/ml.

Protein Kinase C Theta, ELISA Kit - MBS041881 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS745630 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 pg/mL.

Protein Kinase C Theta, ELISA Kit - MBS050080 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Theta, ELISA Kit - MBS745129 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 pg/mL.
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