| Gene Symbol | PRKCQ |
|---|---|
| Entrez Gene | 5588 |
| Alt Symbol | PRKCT, nPKC-theta |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase C, theta |
| Other Description | protein kinase C theta type |
| Swissprots | Q64FY5 Q3MJF1 Q14DH6 Q9H508 B4DF52 Q9H549 Q04759 |
| Accessions | EAW86392 EAW86393 EAW86394 Q04759 AA234440 AI570478 AK293935 BAG57313 AK308099 AK312411 AU099414 AY702977 AAU29340 BC101465 AAI01466 BC113359 AAI13360 BC143222 BF592799 BX647657 HQ258485 ADR83239 L01087 AAA75571 L07032 AAA60101 R40214 XM_005252496 XP_005252553 XM_005252497 XP_005252554 XM_006717465 XP_006717528 XM_011519547 XP_011517849 XM_011519548 XP_011517850 NM_001242413 NP_001229342 NM_001282644 NP_001269573 NM_001282645 NP_001269574 NM_006257 NP_006248 |
| Function | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non- canonical NF-kappa-B (NFKB2) pathway. In the signaling p |
| Subcellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse. |
| Tissue Specificity | Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets. {ECO:0000269|PubMed:7686153}. |
| Top Pathways | Tight junction, T cell receptor signaling pathway, Adipocytokine signaling pathway, Vascular smooth muscle contraction, Measles |