PRKCQ

Gene Symbol	PRKCQ
Entrez Gene	5588
Alt Symbol	PRKCT, nPKC-theta
Species	Human
Gene Type	protein-coding
Description	protein kinase C, theta
Other Description	protein kinase C theta type
Swissprots	Q64FY5 Q3MJF1 Q14DH6 Q9H508 B4DF52 Q9H549 Q04759
Accessions	EAW86392 EAW86393 EAW86394 Q04759 AA234440 AI570478 AK293935 BAG57313 AK308099 AK312411 AU099414 AY702977 AAU29340 BC101465 AAI01466 BC113359 AAI13360 BC143222 BF592799 BX647657 HQ258485 ADR83239 L01087 AAA75571 L07032 AAA60101 R40214 XM_005252496 XP_005252553 XM_005252497 XP_005252554 XM_006717465 XP_006717528 XM_011519547 XP_011517849 XM_011519548 XP_011517850 NM_001242413 NP_001229342 NM_001282644 NP_001269573 NM_001282645 NP_001269574 NM_006257 NP_006248
Function	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non- canonical NF-kappa-B (NFKB2) pathway. In the signaling p
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.
Tissue Specificity	Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets. {ECO:0000269|PubMed:7686153}.
Top Pathways	Tight junction, T cell receptor signaling pathway, Adipocytokine signaling pathway, Vascular smooth muscle contraction, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PKC theta full length protein - ab56641 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PKC theta protein fragment - ab159209 from Abcam Category Protein Source Wheat germ Species Human

PRKCQ / PKC-Theta Antibody Blocking Peptide - LS-E8617 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PKC theta Protein - H00005588-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PKC theta Recombinant Protein - P4763 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

PKC theta Peptide - P2115 from Novus Biologicals Category Peptide Species Human

PKC-theta-Antibody-C-term-Blocking-Peptide - BP7027a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PKC-t Protein (OPPA01182) - OPPA01182 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Sf9 Insect Cells

PRKCQ peptide - orb217802 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey, Dog

PRKCQ / PRKCT - H00005588-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKCQ / PRKCT - H00005588-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKCQ / PRKCT - P4763 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

cyclin-dependent kinase 16, Human Recombinant - 228-11260-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human PKC theta [+His] [from Sf9] - 228-11260-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Sf9 insect cells. Species Human

Recombinant Human PKC theta [+His] [from Sf9] - 228-11260-3 from RayBiotech Category Protein Prices $2,950.00 Sizes 3 µg Source Sf9 insect cells. Species Human

PKC-t Human - PKPS-331 from NeoScientific Category Protein Prices $65.00, $169.00, $6,240.00 Sizes 2 µg, 10 µg, 1 mg Source Sf9 insect cells. Species Human

Recombinant Human PKC胃 - BP000821-PKA-324 from Syd Labs Category Protein Prices $160.00, $4,800.00 Sizes 10 µg, 1 mg Source Sf9 insect cells-derived. Species Human

PKC-t Human - GWB-3DD0D0 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,350.00 Sizes 2 μg, 10 μg, 1000 μg Species Human

PKC-theta(Phospho-Ser676) Antibody Blocking Peptide - GWB-65D210 from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

PKC-theta(Phospho-Ser695) Antibody Blocking Peptide - GWB-89EE60 from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

Recombinant Human PRKCQ - PRKCQ-30178TH from Creative Biomart Category Protein

Recombinant Human Protein Kinase C, Theta, GST-tagged, Active - PRKCQ-408H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human Protein Kinase C, Theta, His-tagged - PRKCQ-916H from Creative Biomart Category Protein Source Human

PKC-t Human - LKP-739 from Reagent Proteins Category Protein Prices $348.00, $6,171.00 Sizes 10.00 µg, 1 mg Source Sf9 insect cells Species Human

Recombinant Protein Kinase C Theta (PKCq) - RPA494Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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