PRKCQ

Gene Symbol	PRKCQ
Entrez Gene	5588
Alt Symbol	PRKCT, nPKC-theta
Species	Human
Gene Type	protein-coding
Description	protein kinase C, theta
Other Description	protein kinase C theta type
Swissprots	Q64FY5 Q3MJF1 Q14DH6 Q9H508 B4DF52 Q9H549 Q04759
Accessions	EAW86392 EAW86393 EAW86394 Q04759 AA234440 AI570478 AK293935 BAG57313 AK308099 AK312411 AU099414 AY702977 AAU29340 BC101465 AAI01466 BC113359 AAI13360 BC143222 BF592799 BX647657 HQ258485 ADR83239 L01087 AAA75571 L07032 AAA60101 R40214 XM_005252496 XP_005252553 XM_005252497 XP_005252554 XM_006717465 XP_006717528 XM_011519547 XP_011517849 XM_011519548 XP_011517850 NM_001242413 NP_001229342 NM_001282644 NP_001269573 NM_001282645 NP_001269574 NM_006257 NP_006248
Function	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non- canonical NF-kappa-B (NFKB2) pathway. In the signaling p
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Note=In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.
Tissue Specificity	Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets. {ECO:0000269|PubMed:7686153}.
Top Pathways	Tight junction, T cell receptor signaling pathway, Adipocytokine signaling pathway, Vascular smooth muscle contraction, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PKC θ CRISPR/Cas9 KO Plasmid (h) - sc-418112 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC θ HDR Plasmid (h) - sc-418112-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC θ Double Nickase Plasmid (h) - sc-418112-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC θ Double Nickase Plasmid (h2) - sc-418112-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC θ CRISPR Activation Plasmid (h) - sc-418112-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC θ CRISPR Activation Plasmid (h2) - sc-418112-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC θ Lentiviral Activation Particles (h) - sc-418112-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC θ Lentiviral Activation Particles (h2) - sc-418112-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PKC θ siRNA (h) - sc-36252 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC θ shRNA Plasmid (h) - sc-36252-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC θ shRNA (h) Lentiviral Particles - sc-36252-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU093601 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK1841 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1839 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1840 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2335 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2335 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

PRKCQ siRNA (Human) - CRH3758 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PKC theta RNAi - H00005588-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human PRKCQ (NM_006257.3) - SHH382876 from Creative biogene Category siRNA Species Reactivities Human

Human PRKCQ siRNA - orb264260 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PRKCQ shRNA Plasmid (Human) - CHH3758 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PRKCQ miRNA 3'UTR clone - MiUTR1H-08278 from Creative biogene Species Reactivities Human

PRKCQ miRNA 3'UTR clone - MiUTR3H-03384 from Creative biogene Species Reactivities Human

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