| Gene Symbol |
CPSF3
|
| Entrez Gene |
51692
|
| Alt Symbol |
CPSF-73, CPSF73
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cleavage and polyadenylation specific factor 3, 73kDa
|
| Other Description |
cleavage and polyadenylation specificity factor subunit 3|mRNA 3'-end-processing endonuclease CPSF-73
|
| Swissprots |
Q53RS2 Q96F36 O14769 Q9UKF6
|
| Accessions |
AAY14858 EAX00989 EAX00990 Q9UKF6 AA635764 AF017269 AAB70268 AF171877 AAF00224 AK025440 AK223487 BAD97207 AK298918 BAG61024 BC011654 AAH11654 BC014106 BC020211 AAH20211 BC030988 AAH30988 BC043432 DC420903 EF036508 ABO65094 EU176402 ABW03853 XM_005246167 XP_005246224 XM_005246168 XP_005246225 XM_011510362 XP_011508664 NM_016207 NP_057291
|
| Function |
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete remov
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15037765}.
|
| Top Pathways |
mRNA surveillance pathway
|