CPSF3

Gene Symbol	CPSF3
Entrez Gene	51692
Alt Symbol	CPSF-73, CPSF73
Species	Human
Gene Type	protein-coding
Description	cleavage and polyadenylation specific factor 3, 73kDa
Other Description	cleavage and polyadenylation specificity factor subunit 3|mRNA 3'-end-processing endonuclease CPSF-73
Swissprots	Q53RS2 Q96F36 O14769 Q9UKF6
Accessions	AAY14858 EAX00989 EAX00990 Q9UKF6 AA635764 AF017269 AAB70268 AF171877 AAF00224 AK025440 AK223487 BAD97207 AK298918 BAG61024 BC011654 AAH11654 BC014106 BC020211 AAH20211 BC030988 AAH30988 BC043432 DC420903 EF036508 ABO65094 EU176402 ABW03853 XM_005246167 XP_005246224 XM_005246168 XP_005246225 XM_011510362 XP_011508664 NM_016207 NP_057291
Function	Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete remov
Subcellular Location	Nucleus {ECO:0000269|PubMed:15037765}.
Top Pathways	mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CPSF3 293T Cell Transient Overexpression Lysate(Denatured) - H00051692-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CPSF3 overexpression lysate - LY414121 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CPSF3 293 Cell Lysate - 406784 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CPSF73 Overexpression Lysate (Native) - NBP2-07071 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CPSF3 Over-expression Lysate Product - GWB-5C9596 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

CPSF73 Overexpression Lysate (Denatured) - H00051692-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

CPSF73 Overexpression Lysate (Denatured) - H00051692-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human CPSF3 Knockdown Stable Cell Line - CSC-DC003590 from Creative biogene Category Cell Line Species Human

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