CPSF3

Gene Symbol CPSF3
Entrez Gene 51692
Alt Symbol CPSF-73, CPSF73
Species Human
Gene Type protein-coding
Description cleavage and polyadenylation specific factor 3, 73kDa
Other Description cleavage and polyadenylation specificity factor subunit 3|mRNA 3'-end-processing endonuclease CPSF-73
Swissprots Q53RS2 Q96F36 O14769 Q9UKF6
Accessions AAY14858 EAX00989 EAX00990 Q9UKF6 AA635764 AF017269 AAB70268 AF171877 AAF00224 AK025440 AK223487 BAD97207 AK298918 BAG61024 BC011654 AAH11654 BC014106 BC020211 AAH20211 BC030988 AAH30988 BC043432 DC420903 EF036508 ABO65094 EU176402 ABW03853 XM_005246167 XP_005246224 XM_005246168 XP_005246225 XM_011510362 XP_011508664 NM_016207 NP_057291
Function Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete remov
Subcellular Location Nucleus {ECO:0000269|PubMed:15037765}.
Top Pathways mRNA surveillance pathway

Human CPSF73 full length protein - ab153359 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153359 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human CPSF73 protein fragment - ab153360 from Abcam

Category Protein
Source Wheat germ
Species Human
ab153360 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CPSF3 / CPSF Antibody Blocking Peptide - LS-E3600 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human CPSF73 Protein - H00051692-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human CPSF73 Protein - H00051692-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CPSF3-Antibody-Center-Blocking-Peptide - BP14804c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CPSF3 Blocking Peptide - 33R-5592 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

CPSF3 Blocking Peptide - 33R-1889 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

CPSF3 - H00051692-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

CPSF3 - H00051692-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

CPSF3 - H00051692-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CPSF3 - H00051692-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CPSF3 fusion protein - Ag2173 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human CPSF3, GST-tagged - CPSF3-11537H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Cleavage and polyadenylation specificity factor subunit 3(CPSF - CSB-YP890734HU CSB-EP890734HU CSB-BP890734HU CSB-MP890734HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CPSF3 - TP305834 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
CPSF3

CPSF73 Recombinant Protein Antigen - NBP1-85476PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CPSF3 Peptide, Human - M34GP03590H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Cleavage and polyadenylation specificity factor subunit 3 (CPSF3), Recombinant Protein - MBS1349531 from MyBioSource

Category Protein
Prices $1,485.00, $1,485.00, $1,715.00, $1,715.00, $2,540.00, $2,540.00, $2,980.00, $2,980.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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