| Gene Symbol |
NDST3
|
| Entrez Gene |
9348
|
| Alt Symbol |
HSST3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
|
| Other Description |
GlcNAc N-deacetylase/ N-sulfotransferase 3|N-HSST 3|N-heparan sulfate sulfotransferase 3|NDST-3|bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3|glucosaminyl N-deacetylase/N-sulfotransferase 3|hNDST-3
|
| Swissprots |
Q4W5C1 B4DI67 Q9UP21 O95803 Q6UWC5 Q4W5D0
|
| Accessions |
AAY41001 AAY41056 EAX06313 O95803 AF074924 AAD15978 AF076605 AAD46061 AK295439 BAG58379 AY358852 AAQ89211 BC034037 BC109309 AAI09310 BC109310 AAI09311 BE348441 HQ234312 XM_006714416 XP_006714479 XM_011532414 XP_011530716 XM_011532415 XP_011530717 XM_011532416 XP_011530718 NM_004784 NP_004775
|
| Function |
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. {ECO:0000269|PubMed:9915799}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle. {ECO:0000269|PubMed:9915799}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|
![Western Blot: NDST3 Overexpression Lysate (Adult Normal) [NBL1-13533] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NDST3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2393_NDST3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13533-img0002.jpg)