| Gene Symbol | NDST3 |
|---|---|
| Entrez Gene | 9348 |
| Alt Symbol | HSST3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 |
| Other Description | GlcNAc N-deacetylase/ N-sulfotransferase 3|N-HSST 3|N-heparan sulfate sulfotransferase 3|NDST-3|bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3|glucosaminyl N-deacetylase/N-sulfotransferase 3|hNDST-3 |
| Swissprots | Q4W5C1 B4DI67 Q9UP21 O95803 Q6UWC5 Q4W5D0 |
| Accessions | AAY41001 AAY41056 EAX06313 O95803 AF074924 AAD15978 AF076605 AAD46061 AK295439 BAG58379 AY358852 AAQ89211 BC034037 BC109309 AAI09310 BC109310 AAI09311 BE348441 HQ234312 XM_006714416 XP_006714479 XM_011532414 XP_011530716 XM_011532415 XP_011530717 XM_011532416 XP_011530718 NM_004784 NP_004775 |
| Function | Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. {ECO:0000269|PubMed:9915799}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle. {ECO:0000269|PubMed:9915799}. |
| Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |