Gene Symbol | POMP |
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Entrez Gene | 51371 |
Alt Symbol | C13orf12, HSPC014, PNAS-110, UMP1 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome maturation protein |
Other Description | 2510048O06Rik|hUMP1|proteassemblin|protein UMP1 homolog|voltage-gated K channel beta subunit 4.1|voltage-gated potassium channel beta subunit 4.1 |
Swissprots | Q9HB69 Q9Y244 D6MXU3 A5HKJ2 |
Accessions | EAX08434 EAX08435 Q9Y244 AF077200 AAD26995 AF125097 AAD39914 AF262975 AAK58521 AF275807 AAG23819 AK312118 BAG35054 BC003390 AAH03390 BC014334 AAH14334 CD369437 DQ894129 ABM85055 EF535527 ABQ08566 GU045555 ADE92939 GU045556 ADE92940 NM_015932 NP_057016 |
Function | Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum. {ECO:0000269|PubMed:15944226, ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17948026}. |
Subcellular Location | Cytoplasm, cytosol. Nucleus. Microsome membrane. |
Tissue Specificity | Strongly expressed from the basal layer to the granular layer of healthy epidermis, whereas in KLICK patients there is a gradual decrease of expression toward the granular layer. {ECO:0000269|PubMed:20226437}. |
Top Pathways | Proteasome |
Proteassemblin (F-3) - sc-271491 from Santa Cruz Biotechnology
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Proteassemblin (B-1) - sc-393267 from Santa Cruz Biotechnology
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Proteassemblin (FL-141) - sc-68414 from Santa Cruz Biotechnology
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Proteassemblin (H-3) - sc-271414 from Santa Cruz Biotechnology
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Proteassemblin (T-17) - sc-67801 from Santa Cruz Biotechnology
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Proteassemblin (E-20) - sc-67799 from Santa Cruz Biotechnology
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Anti-HSPC014 antibody - ab16424 from Abcam
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Anti-HSPC014 antibody - ab169974 from Abcam
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Anti-HSPC014 antibody [EPR10177] - ab170865 from Abcam
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Anti-HSPC014 antibody - C-terminal - ab180209 from Abcam
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Anti-POMP / HSPC014 Antibody (C-Terminus) - LS-C345999 from LifeSpan Bioscience
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Anti-POMP / HSPC014 Antibody (aa105-131) - LS-C203896 from LifeSpan Bioscience
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HSPC014 Antibody - NBP1-90734 from Novus Biologicals
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Anti-POMP antibody produced in rabbit - HPA026995 from Sigma-Aldrich
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Anti-C13orf12 antibody produced in chicken - GW21249 from Sigma-Aldrich
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Anti-POMP antibody produced in mouse - SAB1409419 from Sigma-Aldrich
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ANTI-POMP(C-TERMINAL) antibody produced in rabbit - SAB1307267 from Sigma-Aldrich
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POMP Antibody - C-terminal region (ARP56777_P050) - ARP56777_P050 from Aviva Systems Biology
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POMP-Antibody-C-term - AP20420b from Abgent, a WuXi AppTec company
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POMP Antibody - C-terminal region (OAAB17946) - OAAB17946 from Aviva Systems Biology
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POMP antibody - 70R-19417 from Fitzgerald
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Anti -HSPC014 (Chromosome 13 Open Reading Frame 12) - H7660 from USBiological Life Science
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HSPC014 antibody - orb184246 from Biorbyt
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POMP antibody - 15046-1-AP from Acris Antibodies
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POMP antibody - H00051371-B02P from Acris Antibodies
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