| Gene Symbol |
POMP
|
| Entrez Gene |
51371
|
| Alt Symbol |
C13orf12, HSPC014, PNAS-110, UMP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasome maturation protein
|
| Other Description |
2510048O06Rik|hUMP1|proteassemblin|protein UMP1 homolog|voltage-gated K channel beta subunit 4.1|voltage-gated potassium channel beta subunit 4.1
|
| Swissprots |
Q9HB69 Q9Y244 D6MXU3 A5HKJ2
|
| Accessions |
EAX08434 EAX08435 Q9Y244 AF077200 AAD26995 AF125097 AAD39914 AF262975 AAK58521 AF275807 AAG23819 AK312118 BAG35054 BC003390 AAH03390 BC014334 AAH14334 CD369437 DQ894129 ABM85055 EF535527 ABQ08566 GU045555 ADE92939 GU045556 ADE92940 NM_015932 NP_057016
|
| Function |
Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum. {ECO:0000269|PubMed:15944226, ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17948026}.
|
| Subcellular Location |
Cytoplasm, cytosol. Nucleus. Microsome membrane.
|
| Tissue Specificity |
Strongly expressed from the basal layer to the granular layer of healthy epidermis, whereas in KLICK patients there is a gradual decrease of expression toward the granular layer. {ECO:0000269|PubMed:20226437}.
|
| Top Pathways |
Proteasome
|
![Western Blot: HSPC014 Overexpression Lysate (Adult Normal) [NBL1-14600] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HSPC014.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/10868_HSPC014%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14600-img0002.jpg)