FZD8

Gene Symbol FZD8
Entrez Gene 8325
Alt Symbol FZ-8, hFZ8
Species Human
Gene Type protein-coding
Description frizzled class receptor 8
Other Description frizzled 8, seven transmembrane spanning receptor|frizzled family receptor 8|frizzled homolog 8|frizzled-8
Swissprots Q9H461
Accessions EAW85909 Q9H461 AB043703 BAB41064 AF086500 BC111845 AAI11846 NM_031866 NP_114072
Function Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. {ECO:0000269|PubMed:11448771}.
Subcellular Location Membrane; Multi-pass membrane protein. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}.
Tissue Specificity Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
Top Pathways Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

frizzled-8 (E-17) - sc-33504 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
frizzled-8 (E-17): sc-33504. Western blot analysis of frizzled-8 expression in mouse embryo tissue extract.

frizzled-8 (H-17) - sc-33505 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

frizzled-8 (H-56) - sc-368102 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Frizzled 8 antibody - ab75235 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Frizzled 8 antibody (ab75235) at 1/500 dilutionLane 1 : Jurkat cell extractsLane 2 : Jurkat cell extracts with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Frizzled 8 antibody - ab155650 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Frizzled 8 antibody (ab155650) at 1/10000 dilution + H1299 whole cell lysate at 30 µg

Anti-Frizzled 8 antibody - ab40012 from Abcam

Prices $384.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ICC/IF image of ab40012 stained Hek293 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal donkey serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab40012 at 10µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 donkey anti- goat (ab150133) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-Frizzled 8 antibody - ab135048 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Frizzled 8 antibody (ab135048) at 1/1000 dilution + MCF7 total cell extractsSecondaryRabbit polyclonal to Frizzled 8 (ab135048) at 1/5000 dilution

Anti-Frizzled 8 antibody - ab136236 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Frizzled 8 antibody (ab136236) at 1/500 dilution + HUVEC cell lysates at 30 µg

Anti-Frizzled 8 antibody [EPR7308(2)] - ab155093 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7308(2)
All lanes : Anti-Frizzled 8 antibody [EPR7308(2)] (ab155093) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-Frizzled 8 antibody - Extracellular domain - ab150500 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cerebellum purkinje neurons labelling Frizzled 8 with ab150500 at 20 µg/ml.

Anti-FZD8 / Frizzled 8 Antibody - LS-C6922 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FZD8 / Frizzled 8 Antibody (Extracellular Domain) - LS-C6923 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-FZD8 / Frizzled 8 Antibody (Biotin) - LS-C6924 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-FZD8 / Frizzled 8 Antibody - LS-C150196 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FZD8 / Frizzled 8 Antibody (aa24-73) - LS-C291966 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FZD8 / Frizzled 8 Antibody (aa684-694) - LS-C54886 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (1 ug/ml) staining of human pancreas lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-FZD8 / Frizzled 8 Antibody (aa486-535) - LS-C120662 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, using FZD8 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-FZD8 / Frizzled 8 Antibody (aa144-193) - LS-C110624 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FZD8 / Frizzled 8 antibody LS-C110624 Western blot of MCF7 cell lysate.

Anti-FZD8 / Frizzled 8 Antibody (Lys528) - LS-C177154 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Frizzled-8 (K528) pAb in extracts from Jurkat cells.

Anti-FZD8 / Frizzled 8 Antibody (Extracellular Domain) IHC-plus™ - LS-A4767 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FZD8 / Frizzled 8 antibody IHC of human fetal kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A4767 dilution 8-20 ug/ml.

Anti-FZD8 / Frizzled 8 Antibody (aa31-80) - LS-C120599 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of A549 cells, using FZD8 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-FZD8 / Frizzled 8 Antibody (N-Terminus) IHC-plus™ - LS-A4766 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FZD8 / Frizzled 8 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FZD8 / Frizzled 8 Antibody (N-Terminus) IHC-plus™ - LS-A4776 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FZD8 / Frizzled 8 antibody IHC of human brain, substantia nigra. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Frizzled-8 Antibody - NB100-2439 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: Frizzled-8 Antibody [NB100-2439] - (1ug/ml) staining of human pancreas lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Frizzled-8 Antibody - NBP1-87410 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Frizzled-8 Antibody [NBP1-87410] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).
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