| Gene Symbol |
FZD8
|
| Entrez Gene |
8325
|
| Alt Symbol |
FZ-8, hFZ8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
frizzled class receptor 8
|
| Other Description |
frizzled 8, seven transmembrane spanning receptor|frizzled family receptor 8|frizzled homolog 8|frizzled-8
|
| Swissprots |
Q9H461
|
| Accessions |
EAW85909 Q9H461 AB043703 BAB41064 AF086500 BC111845 AAI11846 NM_031866 NP_114072
|
| Function |
Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. {ECO:0000269|PubMed:11448771}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}.
|
| Tissue Specificity |
Most abundant in fetal kidney, followed by brain and lung. In adult tissues, expressed in kidney, heart, pancreas and skeletal muscle.
|
| Top Pathways |
Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway
|